FOG11107
EOG8R228V

sce:PAN2

Genes: 33

SGD Description
Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes


PomBase Description
ubiquitin C-terminal hydrolase, poly(A)-specific ribonuclease complex subunit Pan2 (predicted)


AspGD Description
Ortholog(s) have cytoplasm localization


References

Lowell JE, et al. (1992 Nov). 3'-UTR-dependent deadenylation by the yeast poly(A) nuclease.

Sachs AB, et al. (1992 Sep 18). Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast.

Boeck R, et al. (1996 Jan 5). The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.

Brown CE, et al. (1996 Oct). PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae.

Brown CE, et al. (1998 Nov). Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation.

Tucker M, et al. (2001 Feb 9). The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.

Hammet A, et al. (2002 Jun 21). Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.

Mangus DA, et al. (2004 Jun). Positive and negative regulation of poly(A) nuclease.

Mangus DA, et al. (2004 May). Identification of factors regulating poly(A) tail synthesis and maturation.

Dunn EF, et al. (2005 Jan 1). Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.

Dheur S, et al. (2005 Jul 1). Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.

Hilgers V, et al. (2006 Oct). Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae.

Morozov IY, et al. (2010 Jan). CUCU modification of mRNA promotes decapping and transcript degradation in Aspergillus nidulans.

Schäfer IB, et al. (2014 Jul). The structure of the Pan2-Pan3 core complex reveals cross-talk between deadenylase and pseudokinase.

Wolf J, et al. (2014 Jul 17). Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 12 genes with posterior transmembrane prediction > 50%