FOG11027
EOG8R7SRP

sce:IST2

Genes: 34

SGD Description
Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process


PomBase Description
transmembrane transporter (predicted)


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN7165, A. fumigatus Af293 : Afu4g03330, A. oryzae RIB40 : AO090011000165, Aspergillus wentii : Aspwe1_0053298 and Aspergillus sydowii : Aspsy1_0060563|Ortholog(s) have phospholipid scramblase activity, voltage-gated calcium channel activity, role in ion transmembrane transport, phospholipid translocation and endoplasmic reticulum, integral component of membrane localization


References

Takizawa PA, et al. (2000 Oct 13). Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier.

Kim Y, et al. (2005 Feb). Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%