FOG11024
EOG8FXPPV
EOG8R7SRZ

sce:JSN1;PUF2

Genes: 35

SGD Description
Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication|PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication


PomBase Description
RNA-binding protein|RNA-binding protein (predicted)


AspGD Description
Has domain(s) with predicted RNA binding, nucleic acid binding, nucleotide binding activity


References

Machin NA, et al. (1995 Sep). Microtubule stability in budding yeast: characterization and dosage suppression of a benomyl-dependent tubulin mutant.

Olivas W, et al. (2000 Dec 1). The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast.

Gerber AP, et al. (2004 Mar). Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%