FOG10991
EOG8RBP0H

sce:RAV1

Genes: 32

SGD Description
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate


PomBase Description
RAVE complex subunit Rav1


AspGD Description
Ortholog(s) have protein complex binding activity and role in cellular response to calcium ion, cellular response to zinc ion, early endosome to late endosome transport, regulation of protein complex assembly, vacuolar acidification


References

Seol JH, et al. (2001 Apr). Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.

Smardon AM, et al. (2002 Apr 19). The RAVE complex is essential for stable assembly of the yeast V-ATPase.

Sipos G, et al. (2004 Jul). Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Dawson K, et al. (2008 Jun). Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Tay Z, et al. (2013). Cellular robustness conferred by genetic crosstalk underlies resistance against chemotherapeutic drug doxorubicin in fission yeast.

Tay Z, et al. (2014). P-glycoprotein and vacuolar ATPase synergistically confer anthracycline resistance to fission yeast and human cells.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Nguyen TT, et al. (2015 Feb 11). Fitness profiling links topoisomerase II regulation of centromeric integrity to doxorubicin resistance in fission yeast.

Tang MY, et al. (2015 May 10). Two fission yeast high mobility group box proteins in the maintenance of genomic integrity following doxorubicin insult.

Nguyen TT, et al. (2016 Jan 21). Predicting chemotherapeutic drug combinations through gene network profiling.

Nguyen TT, et al. (2016 Mar). Calcium modulation of doxorubicin cytotoxicity in yeast and human cells.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%