FOG10981
EOG86M939
EOG8RBP21

sce:absent

Genes: 12

AspGD Description
Ortholog(s) have isopenicillin-N N-acyltransferase activity and role in penicillin biosynthetic process


References

Edwards GF, et al. (1974 Oct). Mutants of Aspergillus nidulans impaired in penicillin biosynthesis.

MacCabe AP, et al. (1990 Jan). The Aspergillus nidulans npeA locus consists of three contiguous genes required for penicillin biosynthesis.

Whiteman PA, et al. (1990 Mar 26). Acyl coenzyme A: 6-aminopenicillanic acid acyltransferase from Penicillium chrysogenum and Aspergillus nidulans.

Montenegro E, et al. (1990 May). Cloning, characterization of the acyl-CoA:6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene.

Tobin MB, et al. (1990 Oct). Molecular characterization of the acyl-coenzyme A:isopenicillin N acyltransferase gene (penDE) from Penicillium chrysogenum and Aspergillus nidulans and activity of recombinant enzyme in Escherichia coli.

MacCabe AP, et al. (1991 Jan). Identification and expression of the ACV synthetase gene.

Lloyd AT, et al. (1991 Nov). Codon usage in Aspergillus nidulans.

Montenegro E, et al. (1992 Nov). Resolution of chromosomes III and VI of Aspergillus nidulans by pulsed-field gel electrophoresis shows that the penicillin biosynthetic pathway genes pcbAB, pcbC, and penDE are clustered on chromosome VI (3.0 megabases).

Cantoral JM, et al. (1993 Jan 5). Biochemical characterization and molecular genetics of nine mutants of Penicillium chrysogenum impaired in penicillin biosynthesis.

Martín JF, et al. (1994). Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins.

Brakhage AA, et al. (1994 Jan). Analysis of the regulation of penicillin biosynthesis in Aspergillus nidulans by targeted disruption of the acvA gene.

Martín JF, et al. (1995). Genes for beta-lactam antibiotic biosynthesis.

Litzka O, et al. (1995 Dec 15). Analysis of the regulation of the Aspergillus nidulans penicillin biosynthesis gene aat (penDE), which encodes acyl coenzyme A:6-aminopenicillanic acid acyltransferase.

Fernández-Cañón JM, et al. (1995 Jan 6). Overexpression of two penicillin structural genes in Aspergillus nidulans.

Litzka O, et al. (1996 Jun 15). The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element.

Brakhage AA, et al. (1997 Mar 1). Molecular regulation of penicillin biosynthesis in Aspergillus (Emericella) nidulans.

Peñalva MA, et al. (1998 Nov). The optimization of penicillin biosynthesis in fungi.

Brakhage AA, et al. (1998 Sep). Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Steidl S, et al. (1999 Jan). AnCF, the CCAAT binding complex of Aspergillus nidulans, contains products of the hapB, hapC, and hapE genes and is required for activation by the pathway-specific regulatory gene amdR.

Gutiérrez S, et al. (1999 Jan-Feb). Gene organization and plasticity of the beta-lactam genes in different filamentous fungi.

Martín JF, et al. (1999 Jan-Feb). Penicillin and cephalosporin biosynthesis: mechanism of carbon catabolite regulation of penicillin production.

van de Kamp M, et al. (1999 Jan-Feb). Compartmentalization and transport in beta-lactam antibiotic biosynthesis by filamentous fungi.

Brakhage AA, et al. (1999 Jul-Aug). HAP-Like CCAAT-binding complexes in filamentous fungi: implications for biotechnology.

Laich F, et al. (1999 Mar). Organization of the gene cluster for biosynthesis of penicillin in Penicillium nalgiovense and antibiotic production in cured dry sausages.

Caruso ML, et al. (2002 Oct 25). Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene.

Busch S, et al. (2003 Jan). Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans.

Fernández FJ, et al. (2003 May). The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa alphabeta heterodimer in an undissociated form.

Brakhage AA, et al. (2004). Regulation of penicillin biosynthesis in filamentous fungi.

Kato M, et al. (2005 Apr). An overview of the CCAAT-box binding factor in filamentous fungi: assembly, nuclear translocation, and transcriptional enhancement.

Herrmann M, et al. (2006 Apr). Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production.

Bok JW, et al. (2006 Jan). Genomic mining for Aspergillus natural products.

Spröte P, et al. (2007 Jul). The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis.

Shwab EK, et al. (2007 Sep). Histone deacetylase activity regulates chemical diversity in Aspergillus.

Atoui A, et al. (2008 Jun). Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase.

Spröte P, et al. (2008 Oct). Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster.

Spröte P, et al. (2009 Mar). Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans.

García-Estrada C, et al. (2009 May 26). Molecular characterization of a fungal gene paralogue of the penicillin penDE gene of Penicillium chrysogenum.

Brakhage AA, et al. (2009 Oct-Nov). Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.

Smidák R, et al. (2010 Mar). Core promoters of the penicillin biosynthesis genes and quantitative RT-PCR analysis of these genes in high and low production strain of Penicillium chrysogenum.

Ramamoorthy V, et al. (2013). The putative C2H2 transcription factor MtfA is a novel regulator of secondary metabolism and morphogenesis in Aspergillus nidulans.

Herr A, et al. (2014 Sep). Improvement of Aspergillus nidulans penicillin production by targeting AcvA to peroxisomes.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%