FOG10907
EOG8RJDGD

sce:KOG1

Genes: 34

SGD Description
Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors


PomBase Description
WD repeat protein, Raptor homolog Mip1


AspGD Description
Ortholog(s) have role in positive regulation of conjugation with cellular fusion and TORC1 complex, cytoplasm localization


References

Shinozaki-Yabana S, et al. (2000 Feb). Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast.

Loewith R, et al. (2002 Sep). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Wedaman KP, et al. (2003 Mar). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.

Araki T, et al. (2005 Oct). LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast.

Alvarez B, et al. (2006 Nov 1). Fission yeast Tor2 promotes cell growth and represses cell differentiation.

Matsuo T, et al. (2007 Apr). Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Hayashi T, et al. (2007 Dec). Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Kanoh J, et al. (2007 Dec). Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Hartmuth S, et al. (2009 Jun 1). Fission yeast Tor1 functions as part of TORC1 to control mitotic entry through the stress MAPK pathway following nutrient stress.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Ikai N, et al. (2011 Nov). The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.

Valbuena N, et al. (2012 Apr 15). The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast.

Takahara T, et al. (2012 Aug). TORC1 of fission yeast is rapamycin-sensitive.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Iida N, et al. (2014 Jun). Mudi, a web tool for identifying mutations by bioinformatics analysis of whole-genome sequence.

Otsubo Y, et al. (2014 Jun 15). S. pombe TORC1 activates the ubiquitin-proteasomal degradation of the meiotic regulator Mei2 in cooperation with Pat1 kinase.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%