FOG05306
EOG84QRJP

sce:CSN12

Genes: 30

SGD Description
Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome


PomBase Description
COP9 signalosome complex subunit 12 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Maytal-Kivity V, et al. (2002 Dec). COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae.

Maytal-Kivity V, et al. (2003 May). The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes.

Wilmes GM, et al. (2008 Dec 5). A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Faza MB, et al. (2009 Mar 23). Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery.

Jimeno S, et al. (2011 Feb). New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Anver S, et al. (2014 Aug). Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%

FOG05307
EOG84QRJP
EOG8SJ3ZG

sce:THP1

Genes: 32

SGD Description
Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding


PomBase Description
TREX complex subunit Pci2 (predicted)


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN5337, A. fumigatus Af293 : Afu6g14290, A. oryzae RIB40 : AO090103000516, Aspergillus wentii : Aspwe1_0100332 and Aspergillus sydowii : Aspsy1_0035762


References

Gallardo M, et al. (2001 Jan). A new hyperrecombination mutation identifies a novel yeast gene, THP1, connecting transcription elongation with mitotic recombination.

Teixeira MT, et al. (2002 Aug 23). Genome-wide nuclear morphology screen identifies novel genes involved in nuclear architecture and gene-silencing in Saccharomyces cerevisiae.

Fischer T, et al. (2002 Nov 1). The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores.

Gallardo M, et al. (2003 Jun 27). Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism.

Rodríguez-Navarro S, et al. (2004 Jan 9). Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery.

Fischer T, et al. (2004 Sep). Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery.

Lemieux C, et al. (2009 Jun). Cotranscriptional recruitment of the nuclear poly(A)-binding protein Pab2 to nascent transcripts and association with translating mRNPs.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Burr R, et al. (2017 Sep 29). Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 18 genes with posterior transmembrane prediction > 50%