FOG05299
EOG84TMTN

sce:absent

Genes: 3

References

Liang Y, et al. (2010 Oct). Role of Candida albicans Aft2p transcription factor in ferric reductase activity, morphogenesis and virulence.

Xu N, et al. (2013). Aft2, a novel transcription regulator, is required for iron metabolism, oxidative stress, surface adhesion and hyphal development in Candida albicans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG05300
EOG84TMTN

sce:AFT1

Genes: 3

SGD Description
Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress


References

Gil R, et al. (1991 Jan). RCS1, a gene involved in controlling cell size in Saccharomyces cerevisiae.

Yamaguchi-Iwai Y, et al. (1995 Mar 15). AFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.

Casas C, et al. (1997 Jun 15). The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG05301
EOG84TMTN

sce:AFT2

Genes: 4

SGD Description
Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication


References

Rutherford JC, et al. (2001 Dec 4). A second iron-regulatory system in yeast independent of Aft1p.

Blaiseau PL, et al. (2001 Sep 7). Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast.

Rutherford JC, et al. (2003 Jul 25). Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements.

Courel M, et al. (2005 Aug). Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1.

Rutherford JC, et al. (2005 Mar 18). Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%