FOG05272
EOG80RXWS
EOG85HQGC

sce:GAL4

Genes: 39

SGD Description
DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p


AspGD Description
Ortholog(s) have RNA polymerase II core promoter proximal region sequence-specific DNA binding and RNA polymerase II transcription factor activity, more|Has domain(s) with predicted DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, zinc ion binding activity and role in regulation of transcription, DNA-templated, transcription, DNA-templated


References

Arst HN Jr, et al. (1970). Molybdate metabolism in Aspergillus nidulans. II. Mutations affecting phosphatase activity or galactose utilization.

Roberts CF, et al. (1970 Feb 24). Enzyme lesions in galactose non-utilising mutants of Aspergillus nidulans.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Laughon A, et al. (1984 Feb). Primary structure of the Saccharomyces cerevisiae GAL4 gene.

Salmeron JM Jr, et al. (1986 Oct 10). Analysis of the Kluyveromyces lactis positive regulatory gene LAC9 reveals functional homology to, but sequence divergence from, the Saccharomyces cerevisiae GAL4 gene.

Johnston M, et al. (1987 Jul 23-29). Genetic evidence that zinc is an essential co-factor in the DNA binding domain of GAL4 protein.

Wray LV Jr, et al. (1987 Mar). Characterization of a positive regulatory gene, LAC9, that controls induction of the lactose-galactose regulon of Kluyveromyces lactis: structural and functional relationships to GAL4 of Saccharomyces cerevisiae.

Gadhavi PL, et al. (1990 Dec 10). Complete assignment of the 1H NMR spectrum and secondary structure of the DNA binding domain of GAL4.

Kuger P, et al. (1990 Feb 25). A mutation in the Zn-finger of the GAL4 homolog LAC9 results in glucose repression of its target genes.

Pan T, et al. (1990 Mar). GAL4 transcription factor is not a "zinc finger" but forms a Zn(II)2Cys6 binuclear cluster.

Pan T, et al. (1991 Apr 30). Sequential assignments of the 1H NMR resonances of Zn(II)2 and 113Cd(II)2 derivatives of the DNA-binding domain of the GAL4 transcription factor reveal a novel structural motif for specific DNA recognition.

Baleja JD, et al. (1992 Apr 2). Solution structure of the DNA-binding domain of Cd2-GAL4 from S. cerevisiae.

Kraulis PJ, et al. (1992 Apr 2). Structure of the DNA-binding domain of zinc GAL4.

Marmorstein R, et al. (1992 Apr 2). DNA recognition by GAL4: structure of a protein-DNA complex.

Gardner KH, et al. (1995 Oct). Solution structure of the Kluyveromyces lactis LAC9 Cd2 Cys6 DNA-binding domain.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Koh SS, et al. (1998 May). An activator target in the RNA polymerase II holoenzyme.

Chang PK, et al. (2000 Apr 25). Characterization of the Aspergillus parasiticus major nitrogen regulatory gene, areA.

Jeong CJ, et al. (2001 Aug 7). Evidence that Gal11 protein is a target of the Gal4 activation domain in the mediator.

Piskacek S, et al. (2007 Jun). Nine-amino-acid transactivation domain: establishment and prediction utilities.

Christensen U, et al. (2011 Oct). Unique regulatory mechanism for D-galactose utilization in Aspergillus nidulans.

Gruben BS, et al. (2012 Nov 16). GalX regulates the D-galactose oxido-reductive pathway in Aspergillus niger.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 27 genes with posterior transmembrane prediction > 50%

FOG05273
EOG85HQGC

sce:absent

Genes: 2

AspGD Description
Has domain(s) with predicted DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding, zinc ion binding activity and role in regulation of transcription, DNA-templated, transcription, DNA-templated

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG05274
EOG85HQGC

sce:absent

Genes: 1

AspGD Description
Putative zinc-binding transcription factor, involved in regulation of galactose catabolism via the oxidoreductive pathway


References

Arst HN Jr, et al. (1970). Molybdate metabolism in Aspergillus nidulans. II. Mutations affecting phosphatase activity or galactose utilization.

Roberts CF, et al. (1970 Feb 24). Enzyme lesions in galactose non-utilising mutants of Aspergillus nidulans.

Clutterbuck AJ, et al. (1973 Jun). Gene symbols in Aspergillus nidulans.

Clutterbuck AJ, et al. (1997 Jun). The validity of the Aspergillus nidulans linkage map.

Chang PK, et al. (2000 Apr 25). Characterization of the Aspergillus parasiticus major nitrogen regulatory gene, areA.

Christensen U, et al. (2011 Oct). Unique regulatory mechanism for D-galactose utilization in Aspergillus nidulans.

Gruben BS, et al. (2012 Nov 16). GalX regulates the D-galactose oxido-reductive pathway in Aspergillus niger.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%