FOG05254
EOG85X6CJ

sce:absent

Genes: 6

PomBase Description
telomere end-binding protein Pot1


AspGD Description
Ortholog(s) have G-rich strand telomeric DNA binding activity and role in chromosome segregation, negative regulation of telomere maintenance via telomerase, regulation of mitotic nuclear division, telomere capping


References

Morris NR, et al. (1975 Dec). Mitotic mutants of Aspergillus nidulans.

Baumann P, et al. (2001 May 11). Pot1, the putative telomere end-binding protein in fission yeast and humans.

Lei M, et al. (2002 Dec 10). Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe.

Osmani SA, et al. (2004 Apr). The early impact of genetics on our understanding of cell cycle regulation in Aspergillus nidulans.

Pitt CW, et al. (2004 Jan 15). The pot1+ homologue in Aspergillus nidulans is required for ordering mitotic events.

Trujillo KM, et al. (2005 Mar 11). Extended DNA binding site in Pot1 broadens sequence specificity to allow recognition of heterogeneous fission yeast telomeres.

Martín V, et al. (2007 Aug 28). Protection of telomeres by a conserved Stn1-Ten1 complex.

Xhemalce B, et al. (2007 Jan 16). Role of SUMO in the dynamics of telomere maintenance in fission yeast.

Kibe T, et al. (2007 Jun). Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.

Wang X, et al. (2008 Aug 22). Chromosome fusions following telomere loss are mediated by single-strand annealing.

Miyoshi T, et al. (2008 Jun 6). Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.

Moser BA, et al. (2009 Apr 8). Differential arrival of leading and lagging strand DNA polymerases at fission yeast telomeres.

Moser BA, et al. (2009 Aug). Fission yeast Tel1(ATM) and Rad3(ATR) promote telomere protection and telomerase recruitment.

Takahashi K, et al. (2011 Feb). Fission yeast Pot1 and RecQ helicase are required for efficient chromosome segregation.

Ukimori S, et al. (2012). A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug.

Nandakumar J, et al. (2012 Jan). DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe.

Altschuler SE, et al. (2012 Oct 9). A small molecule inhibitor of Pot1 binding to telomeric DNA.

Choi ES, et al. (2012 Sep). Factors that promote H3 chromatin integrity during transcription prevent promiscuous deposition of CENP-A(Cnp1) in fission yeast.

Nanbu T, et al. (2013 Mar). Fission yeast RecQ helicase Rqh1 is required for the maintenance of circular chromosomes.

Tadeo X, et al. (2013 Nov 15). Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Jun HI, et al. (2013 Sep 1). Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.

Nakano A, et al. (2014 Apr). Rad51-dependent aberrant chromosome structures at telomeres and ribosomal DNA activate the spindle assembly checkpoint.

Miyagawa K, et al. (2014 Apr 22). SUMOylation regulates telomere length by targeting the shelterin subunit Tpz1(Tpp1) to modulate shelterin-Stn1 interaction in fission yeast.

Garg M, et al. (2014 Aug). Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.

Harland JL, et al. (2014 Oct). Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.

Dickey TH, et al. (2014 Sep). The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability.

Armstrong CA, et al. (2014 Sep 8). Telomerase activation after recruitment in fission yeast.

Nanbu T, et al. (2015). Fission Yeast Exo1 and Rqh1-Dna2 Redundantly Contribute to Resection of Uncapped Telomeres.

Habib AG, et al. (2015 Aug 14). Long G2 accumulates recombination intermediates and disturbs chromosome segregation at dysfunction telomere in Schizosaccharomyces pombe.

Lorenzi LE, et al. (2015 Jan 2). Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Audry J, et al. (2015 Jul 14). RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.

Pan L, et al. (2015 Jun 1). Minishelterins separate telomere length regulation and end protection in fission yeast.

Liu J, et al. (2015 Sep 29). Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.

Webb CJ, et al. (2015 Sep 8). Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding.

Wang J, et al. (2016 Apr 1). The proper connection between shelterin components is required for telomeric heterochromatin assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%