FOG05227
EOG86T1NW

sce:GON7

Genes: 23

SGD Description
Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN11901, A. fumigatus Af293 : Afu7g05785, Neosartorya fischeri NRRL 181 : NFIA_027020 and Aspergillus versicolor : Aspve1_0088350


References

Garay-Arroyo A, et al. (2000 Feb 25). Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.

Kisseleva-Romanova E, et al. (2006 Aug 9). Yeast homolog of a cancer-testis antigen defines a new transcription complex.

Downey M, et al. (2006 Mar 24). A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.

Daugeron MC, et al. (2011 Aug). Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs.

Srinivasan M, et al. (2011 Mar 2). The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Perrochia L, et al. (2013 Feb 1). In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya.

Wan LC, et al. (2013 Jul). Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%