FOG05199
EOG82V6XG
EOG87D7X7
EOG8QJQ3B

sce:CDC25;SDC25

Genes: 37

SGD Description
Membrane bound guanine nucleotide exchange factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; a membrane bound guanine nucleotide exchange factor is also known as a GEF or GDP-release factor|


PomBase Description
Ras1 guanyl-nucleotide exchange factor Efc25|guanyl-nucleotide exchange factor Ste6


AspGD Description
Ortholog(s) have Ras guanyl-nucleotide exchange factor activity


References

Daniel JH, et al. (1986). The CDC25 "Start" gene of Saccharomyces cerevisiae: sequencing of the active C-terminal fragment and regional homologies with rhodopsin and cytochrome P450.

Camonis JH, et al. (1986 Feb). Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae.

Broek D, et al. (1987 Mar 13). The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.

Sipiczki M, et al. (1988 Aug). The role of sterility genes (ste and aff) in the initiation of sexual development in Schizosaccharomyces pombe.

Munder T, et al. (1988 Oct). Domains of the Saccharomyces cerevisiae CDC25 gene controlling mitosis and meiosis.

Hughes DA, et al. (1990 Mar 22). Homologous activators of ras in fission and budding yeast.

Leupold U, et al. (1991 Jul). Pheromone production and response in sterile mutants of fission yeast.

Imai Y, et al. (1991 Jun). Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe.

Wang Y, et al. (1991 Jun). sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.

Jones S, et al. (1991 May). The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras.

Goldberg D, et al. (1993 Apr 1). A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae.

Aono T, et al. (1994 Jun). Mating pheromone-induced expression of the mat1-Pm gene of Schizosaccharomyces pombe: identification of signalling components and characterization of upstream controlling elements.

Hakuno F, et al. (1996 Mar). The Schizosaccharomyces pombe mra1 gene, which is required for cell growth and mating, can suppress the mating inefficiency caused by a deficit in the Ras1 activity.

Maqbool Z, et al. (2003 Sep). MCB-mediated regulation of cell cycle-specific cdc22+ transcription in fission yeast.

Mata J, et al. (2006 Oct 17). Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast.

Shimanuki M, et al. (2013). Klf1, a C2H2 zinc finger-transcription factor, is required for cell wall maintenance during long-term quiescence in differentiated G0 phase.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 9 genes with posterior transmembrane prediction > 50%

FOG05200
EOG87D7X7

sce:absent

Genes: 9

AspGD Description
Ortholog(s) have hyphal tip localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG05201
EOG87D7X7

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted guanyl-nucleotide exchange factor activity, role in regulation of small GTPase mediated signal transduction, small GTPase mediated signal transduction and intracellular localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%