FOG05190
EOG87SR01

sce:UBC6

Genes: 34

SGD Description
Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD


PomBase Description
ubiquitin conjugating enzyme E2 Ubc6 (predicted)


AspGD Description
Ortholog(s) have ubiquitin-protein transferase activity, role in ER-associated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein polyubiquitination and endoplasmic reticulum membrane localization


References

Chen P, et al. (1993 Jul 30). Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor.

Sommer T, et al. (1993 Sep 9). A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum.

Johnson PR, et al. (1998 Jul 24). Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.

Swanson R, et al. (2001 Oct 15). A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.

Neuber O, et al. (2005 Oct). Ubx2 links the Cdc48 complex to ER-associated protein degradation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%

FOG05191
EOG87SR01

sce:absent

Genes: 5

AspGD Description
Has domain(s) with predicted acid-amino acid ligase activity

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG05192
EOG87SR01

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%