FOG05187
EOG880GD0
EOG8PG4G2

sce:SWI5;ACE2

Genes: 38

SGD Description
Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication|Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication


PomBase Description
transcription factor Ace2


AspGD Description
Ortholog(s) have role in asexual spore wall assembly, asexual sporulation resulting in formation of a cellular spore and positive regulation of asexual sporulation resulting in formation of a cellular spore, more


References

Stillman DJ, et al. (1988 Feb). Characterization of a transcription factor involved in mother cell specific transcription of the yeast HO gene.

Nagai K, et al. (1988 Mar 17). Zinc-finger motifs expressed in E. coli and folded in vitro direct specific binding to DNA.

Moll T, et al. (1991 Aug 23). The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5.

Butler G, et al. (1991 Jan). ACE2, an activator of yeast metallothionein expression which is homologous to SWI5.

Neuhaus D, et al. (1992 Nov 20). Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet.

Measday V, et al. (2000 Feb). Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast.

Kelly MT, et al. (2004 Aug). The Candida albicans CaACE2 gene affects morphogenesis, adherence and virulence.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Mulhern SM, et al. (2006 Dec). Candida albicans transcription factor Ace2 regulates metabolism and is required for filamentation in hypoxic conditions.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Song Y, et al. (2008 Dec). Role of the RAM network in cell polarity and hyphal morphogenesis in Candida albicans.

Wang A, et al. (2009 Aug). Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes.

Stichternoth C, et al. (2011 Apr). Sch9 kinase integrates hypoxia and CO2 sensing to suppress hyphal morphogenesis in Candida albicans.

Finkel JS, et al. (2012 Feb). Portrait of Candida albicans adherence regulators.

Heilmann CJ, et al. (2013 Feb). Surface stress induces a conserved cell wall stress response in the pathogenic fungus Candida albicans.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%