FOG05125
EOG89CNQ3

sce:SKT5

Genes: 32

SGD Description
Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication


AspGD Description
Ortholog(s) have enzyme activator activity, role in fungal-type cell wall chitin biosynthetic process and cellular bud neck, cellular bud neck septin ring, incipient cellular bud site localization


References

Kawamoto S, et al. (1993 Aug). A mutant allele skt5 affecting protoplast regeneration and killer toxin resistance has double mutations in its wild-type structural gene in Saccharomyces cerevisiae.

DeMarini DJ, et al. (1997 Oct 6). A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG05126
EOG83J9KZ
EOG89CNQ3

sce:ACK1

Genes: 28

SGD Description
Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria


PomBase Description
chitin synthase regulatory factor-like Cfh1 (predicted)


AspGD Description
Ortholog of A. nidulans FGSC A4 : AN8765, A. fumigatus Af293 : Afu6g02940, A. oryzae RIB40 : AO090026000788, Aspergillus wentii : Aspwe1_0148382 and Aspergillus sydowii : Aspsy1_0060048


References

Peng J, et al. (2003 Aug). A proteomics approach to understanding protein ubiquitination.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%

FOG05127
EOG89CNQ3

sce:SHC1

Genes: 2

SGD Description
Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication


PomBase Description
chitin synthase regulatory factor Cfh2 (predicted)


References

Shinohara A, et al. (1992 May 1). Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein.

Hong SK, et al. (1999 Feb 5). SHC1, a high pH inducible gene required for growth at alkaline pH in Saccharomyces cerevisiae.

Sanz M, et al. (2002 Mar). Control of chitin synthesis through Shc1p, a functional homologue of Chs4p specifically induced during sporulation.

Chen D, et al. (2003 Jan). Global transcriptional responses of fission yeast to environmental stress.

Miki F, et al. (2004 Jan). Two-hybrid search for proteins that interact with Sad1 and Kms1, two membrane-bound components of the spindle pole body in fission yeast.

Matsuo Y, et al. (2004 Sep). Chr4, a Schizosaccharomyces pombe homologue of the Saccharomyces cerevisiae Chs4p/Skt5p protein, is related to septum formation and is required for the proper localization of Chs2.

Lesage G, et al. (2005 Feb 16). An interactional network of genes involved in chitin synthesis in Saccharomyces cerevisiae.

Iwamoto MA, et al. (2005 Mar). Saccharomyces cerevisiae Sps1p regulates trafficking of enzymes required for spore wall synthesis.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Kawashima SA, et al. (2012 Jul 27). Analyzing fission yeast multidrug resistance mechanisms to develop a genetically tractable model system for chemical biology.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%