FOG05117
EOG89GHZJ

sce:MIF2

Genes: 26

SGD Description
Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3


PomBase Description
CENP-C ortholog Cnp3


AspGD Description
Ortholog(s) have centromeric DNA binding activity


References

Brown MT, et al. (1993 Oct). MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae.

Meluh PB, et al. (1995 Jul). Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Dimitrova YN, et al. (2016 Nov 3). Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%