FOG05094
EOG8B2RCB
sce:CAC2
Genes: 34
EOG8B2RCB
sce:CAC2
Genes: 34
SGD Description
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia
PomBase Description
CAF assembly factor (CAF-1) complex subunit B, Pcf2
AspGD Description
Ortholog(s) have role in heterochromatin maintenance, homologous recombination-dependent replication fork processing, mitotic sister chromatid segregation, nucleosome assembly, regulation of phenotypic switching
References
Kaufman PD, et al. (1997 Feb 1). Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
||
FOG05095
EOG8B2RCB
sce:HIR1
Genes: 33
EOG8B2RCB
sce:HIR1
Genes: 33
SGD Description
Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
PomBase Description
hira protein, histone chaperone Hip1
AspGD Description
Ortholog(s) have role in cellular response to nitrogen starvation, chromatin silencing at centromere outer repeat region and chromatin silencing at silent mating-type cassette, more
References
Sherwood PW, et al. (1993 Jan). Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae.
Spector MS, et al. (1997 Feb). Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle.
Kaufman PD, et al. (1998 Aug). Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I.
Qian Z, et al. (1998 Aug). Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins.
DeSilva H, et al. (1998 Feb). Functional dissection of yeast Hir1p, a WD repeat-containing transcriptional corepressor.
Dimova D, et al. (1999 Jul). A role for transcriptional repressors in targeting the yeast Swi/Snf complex.
Sharp JA, et al. (2001 Apr 3). Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing.
Sutton A, et al. (2001 Jun). Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription.
Ng HH, et al. (2002 Apr 1). Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.
Formosa T, et al. (2002 Dec). Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.
Krawitz DC, et al. (2002 Jan). Chromatin assembly factor I mutants defective for PCNA binding require Asf1/Hir proteins for silencing.
Sharp JA, et al. (2002 Jan 1). Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae.
Sharp JA, et al. (2003 Oct 1). The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin.
Crotti LB, et al. (2004 Apr 21). Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae.
Schermer UJ, et al. (2005 Jul 22). Histones are incorporated in trans during reassembly of the yeast PHO5 promoter.
Sharp JA, et al. (2005 Nov). Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.
Prochasson P, et al. (2005 Nov 1). The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF.
Green EM, et al. (2005 Nov 22). Replication-independent histone deposition by the HIR complex and Asf1.
Nourani A, et al. (2006 Feb). Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
5 genes with posterior transmembrane prediction > 50% |
||
FOG05096
EOG8B2RCB
sce:HIR2
Genes: 25
EOG8B2RCB
sce:HIR2
Genes: 25
SGD Description
Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia
PomBase Description
hira protein Slm9
References
Sherwood PW, et al. (1993 Jan). Characterization of HIR1 and HIR2, two genes required for regulation of histone gene transcription in Saccharomyces cerevisiae.
Reed JC, et al. (1994 Jul 8). Cloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II.
Spector MS, et al. (1997 Feb). Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle.
Kaufman PD, et al. (1998 Aug). Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I.
Qian Z, et al. (1998 Aug). Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins.
Dimova D, et al. (1999 Jul). A role for transcriptional repressors in targeting the yeast Swi/Snf complex.
Sharp JA, et al. (2001 Apr 3). Yeast histone deposition protein Asf1p requires Hir proteins and PCNA for heterochromatic silencing.
Ng HH, et al. (2002 Apr 1). Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.
Formosa T, et al. (2002 Dec). Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure.
Prochasson P, et al. (2005 Nov 1). The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF.
Green EM, et al. (2005 Nov 22). Replication-independent histone deposition by the HIR complex and Asf1.
Nourani A, et al. (2006 Feb). Evidence that Spt2/Sin1, an HMG-like factor, plays roles in transcription elongation, chromatin structure, and genome stability in Saccharomyces cerevisiae.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
||
