FOG05043
EOG8CC2GJ

sce:DDC1

Genes: 21

SGD Description
DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress


References

Longhese MP, et al. (1997 Sep 1). The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast.

Paciotti V, et al. (1998 Jul 15). Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p.

Kondo T, et al. (1999 Feb). Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.

Pellicioli A, et al. (1999 Nov 15). Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

Wang H, et al. (2002 Apr). Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway.

Hong EJ, et al. (2002 Feb 1). A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint.

Giannattasio M, et al. (2002 Oct 1). A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1.

Giannattasio M, et al. (2003 Jun 20). Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1.

Majka J, et al. (2003 Mar 4). Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.

Ubersax JA, et al. (2003 Oct 23). Targets of the cyclin-dependent kinase Cdk1.

Majka J, et al. (2004 May 14). Requirement for ATP by the DNA damage checkpoint clamp loader.

Sabbioneda S, et al. (2005 Nov 18). The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.

Majka J, et al. (2005 Sep 28). Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint.

Cardone JM, et al. (2006 Feb 3). Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%