FOG05036
EOG8CFXS4

sce:NAB3

Genes: 30

SGD Description
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability


PomBase Description
poly(A) binding protein Nab3 (predicted)


AspGD Description
Has domain(s) with predicted nucleic acid binding, nucleotide binding activity


References

Wilson SM, et al. (1994 Dec). Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.

Sugimoto K, et al. (1995 Oct 25). Dosage suppressors of the dominant G1 cyclin mutant CLN3-2: identification of a yeast gene encoding a putative RNA/ssDNA binding protein.

Zuin A, et al. (2008 Jul 30). Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Graml V, et al. (2014 Oct 27). A genomic Multiprocess survey of machineries that control and link cell shape, microtubule organization, and cell-cycle progression.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.

Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%