FOG04991
EOG815F1J
EOG8DFN4T

sce:GCN4

Genes: 24

SGD Description
bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels


AspGD Description
bZIP transcription factor; expression enhanced by maltose; the conserved upstream ORF (uORF), An01g07890, was identified in the 5' region of this gene


References

Thireos G, et al. (1984 Aug). 5' untranslated sequences are required for the translational control of a yeast regulatory gene.

Hinnebusch AG, et al. (1984 Oct). Evidence for translational regulation of the activator of general amino acid control in yeast.

Hope IA, et al. (1986 Sep 12). Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast.

Saudek V, et al. (1991 Jun). The solution structure of a leucine-zipper motif peptide.

O'Shea EK, et al. (1991 Oct 25). X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil.

Ellenberger TE, et al. (1992 Dec 24). The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex.

Drysdale CM, et al. (1995 Mar). The transcriptional activator GCN4 contains multiple activation domains that are critically dependent on hydrophobic amino acids.

Eckert DM, et al. (1998 Dec 11). Crystal structure of GCN4-pIQI, a trimeric coiled coil with buried polar residues.

Shemer R, et al. (2002 Aug). Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5.

Czerwinski M, et al. (2002 Feb). Construction of dimeric F(ab) useful in blood group serology.

Leh-Louis V, et al. (2004). Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%