FOG04972
EOG8DZ0C3
sce:UBA2
Genes: 34
EOG8DZ0C3
sce:UBA2
Genes: 34
SGD Description
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
PomBase Description
SUMO activating enzyme E1-type Uba2 (predicted)
AspGD Description
Ortholog(s) have SUMO activating enzyme activity, role in protein sumoylation and nucleus localization
References
Dohmen RJ, et al. (1995 Jul 28). An essential yeast gene encoding a homolog of ubiquitin-activating enzyme.
Johnson ES, et al. (1997 Sep 15). The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer.
Harting R, et al. (2013 Dec). Interplay of the fungal sumoylation network for control of multicellular development.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
11 genes with posterior transmembrane prediction > 50% |
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FOG04973
EOG8DZ0C3
sce:UBA1
Genes: 34
EOG8DZ0C3
sce:UBA1
Genes: 34
SGD Description
Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
PomBase Description
ubiquitin activating enzyme E1
AspGD Description
Ortholog(s) have ATP binding, magnesium ion binding, ubiquitin activating enzyme activity, role in protein ubiquitination and cytosol, nucleus localization
References
McGrath JP, et al. (1989 Aug 3). The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein.
McGrath JP, et al. (1991 Jan). UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.
Azad AK, et al. (1997 May). Isolation and molecular characterization of mRNA transport mutants in Schizosaccharomyces pombe.
Raymond M, et al. (1998 Feb). A Ste6p/P-glycoprotein homologue from the asexual yeast Candida albicans transports the a-factor mating pheromone in Saccharomyces cerevisiae.
Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Lee I, et al. (2008 Jul 25). Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.
Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.
Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Harting R, et al. (2013 Dec). Interplay of the fungal sumoylation network for control of multicellular development.
Olsen SK, et al. (2013 Mar 7). Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Tsutsui Y, et al. (2014 Aug). Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.
Schäfer A, et al. (2014 May). Structure of the ubiquitin-activating enzyme loaded with two ubiquitin molecules.
Raychaudhuri S, et al. (2015 Jun 5). Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.
Zich J, et al. (2016 Feb). Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.
Lv Z, et al. (2017 Feb 16). S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.
Wei Y, et al. (2017 Jun 1). SUMO-Targeted DNA Translocase Rrp2 Protects the Genome from Top2-Induced DNA Damage.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
27 genes with posterior transmembrane prediction > 50% |
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FOG04974
EOG8DZ0C3
sce:UBA3
Genes: 32
EOG8DZ0C3
sce:UBA3
Genes: 32
SGD Description
Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
PomBase Description
NEDD8 activating enzyme E1-type Uba3
AspGD Description
Ortholog(s) have cytosol, nucleus localization
References
Liakopoulos D, et al. (1998 Apr 15). A novel protein modification pathway related to the ubiquitin system.
Osaka F, et al. (2000 Jul 3). Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.
Yashiroda H, et al. (2003 Nov 21). But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast.
Yuasa T, et al. (2004 Nov). An interactive gene network for securin-separase, condensin, cohesin, Dis1/Mtc1 and histones constructed by mass transformation.
Girdwood D, et al. (2012 May 21). Constitutively active Cullin-RING-Ligases fail to rescue loss of NEDD8 conjugation in Schizosaccharomyces pombe.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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