FOG04956
EOG8FFBP7

sce:GPI1

Genes: 34

SGD Description
Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs


PomBase Description
pig-Q


AspGD Description
Ortholog(s) have phosphatidylinositol N-acetylglucosaminyltransferase activity, role in GPI anchor biosynthetic process and endoplasmic reticulum localization


References

Leidich SD, et al. (1996 Nov 1). Gpi1, a Saccharomyces cerevisiae protein that participates in the first step in glycosylphosphatidylinositol anchor synthesis.

Colussi PA, et al. (1997 Feb). The essential Schizosaccharomyces pombe gpil+ gene complements a bakers' yeast GPI anchoring mutant and is required for efficient cell separation.

Sobering AK, et al. (2004 May 28). Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%

FOG04957
EOG8FFBP7

sce:MDM35

Genes: 26

SGD Description
Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress


PomBase Description
mitochondrial distribution and morphology protein Mdm35 (predicted)


References

Andrade MA, et al. (1997 Nov). Characterization of new proteins found by analysis of short open reading frames from the full yeast genome.

Dimmer KS, et al. (2002 Mar). Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae.

Gabriel K, et al. (2007 Jan 19). Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway.

Potting C, et al. (2010 Sep 1). Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.

Tamura Y, et al. (2010 Sep 1). Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Watanabe Y, et al. (2015 Aug 3). Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.

Miliara X, et al. (2015 Jul). Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.

Yu F, et al. (2015 Jul). Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04958
EOG8FFBP7

sce:absent

Genes: 2

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%