FOG04927
EOG8GB5PJ

sce:CET1

Genes: 23

SGD Description
RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of the mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of the guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNA pol II pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is a single bifunctional polypeptide; CET1 has a paralog, CTL1, that arose from the whole genome duplication


References

Itoh N, et al. (1984 Nov 25). Messenger RNA guanlyltransferase from Saccharomyces cerevisiae. II. Catalytic properties.

Itoh N, et al. (1984 Nov 25). Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. I. Purification and subunit structure.

Itoh N, et al. (1987 Feb 15). Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization.

Tsukamoto T, et al. (1997 Oct 9). Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability.

Yamada-Okabe T, et al. (1998 Sep 11). Isolation and characterization of the Candida albicans gene for mRNA 5'-triphosphatase: association of mRNA 5'-triphosphatase and mRNA 5'-guanylyltransferase activities is essential for the function of mRNA 5'-capping enzyme in vivo.

Lima CD, et al. (1999 Nov 24). Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus.

Hausmann S, et al. (2003 Aug 15). Homodimeric quaternary structure is required for the in vivo function and thermal stability of Saccharomyces cerevisiae and Schizosaccharomyces pombe RNA triphosphatases.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04928
EOG8GB5PJ

sce:absent

Genes: 7

PomBase Description
RNA 5'-triphosphatase


AspGD Description
Ortholog(s) have role in cellular response to drug

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04929
EOG8GB5PJ

sce:CTL1

Genes: 2

SGD Description
RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication


References

Rodriguez CR, et al. (1999 May 15). A Saccharomyces cerevisiae RNA 5'-triphosphatase related to mRNA capping enzyme.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%