FOG04913
EOG8GHX6S
sce:NPA3
Genes: 33
EOG8GHX6S
sce:NPA3
Genes: 33
SGD Description
Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
PomBase Description
RNA polymerase II binding AAA family ATPase Npa3 (predicted)
AspGD Description
Ortholog(s) have cytosol localization
References
Dez C, et al. (2004 Jul). Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification.
Keniry ME, et al. (2004 Mar). The identification of Pcl1-interacting proteins that genetically interact with Cla4 may indicate a link between G1 progression and mitotic exit.
Forget D, et al. (2010 Dec). The protein interaction network of the human transcription machinery reveals a role for the conserved GTPase RPAP4/GPN1 and microtubule assembly in nuclear import and biogenesis of RNA polymerase II.
Alonso B, et al. (2011 Jun 1). A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion.
Staresincic L, et al. (2011 Oct 14). GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.
Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.
Alonso B, et al. (2013 Feb 1). Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
Minaker SW, et al. (2013 Mar). Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04914
EOG8GHX6S
sce:GPN2
Genes: 33
EOG8GHX6S
sce:GPN2
Genes: 33
SGD Description
Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion
PomBase Description
conserved ATP binding protein, implicated in sister chromatid cohesion Gpn2 (predicted)
AspGD Description
Ortholog(s) have role in RNA polymerase II complex import to nucleus, RNA polymerase III complex localization to nucleus, establishment of mitotic sister chromatid cohesion and cytosol, nucleus localization
References
Hazbun TR, et al. (2003 Dec). Assigning function to yeast proteins by integration of technologies.
Ben-Aroya S, et al. (2008 Apr 25). Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae.
Ikebe C, et al. (2011). Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.
Alonso B, et al. (2011 Jun 1). A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion.
Staresincic L, et al. (2011 Oct 14). GTP-dependent binding and nuclear transport of RNA polymerase II by Npa3 protein.
Alonso B, et al. (2013 Feb 1). Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
Minaker SW, et al. (2013 Mar). Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
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| Phobius transmembrane predictions
10 genes with posterior transmembrane prediction > 50% |
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FOG04915
EOG8GHX6S
sce:GPN3
Genes: 32
EOG8GHX6S
sce:GPN3
Genes: 32
SGD Description
Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p
PomBase Description
predicted GTPAse with a role in RNA polymerase localization (predicted)
AspGD Description
Ortholog(s) have role in RNA polymerase II complex import to nucleus, RNA polymerase III complex localization to nucleus and cytosol, nucleus localization
References
Alonso B, et al. (2011 Jun 1). A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion.
Alonso B, et al. (2013 Feb 1). Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN.
Minaker SW, et al. (2013 Mar). Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
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