FOG04813
EOG8JDFR0
sce:MKK1;MKK2
Genes: 34
EOG8JDFR0
sce:MKK1;MKK2
Genes: 34
SGD Description
MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication|MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication
PomBase Description
MAP kinase kinase Pek1
AspGD Description
MAP kinase kinase (MAPKK) with a predicted role in the cell wall integrity pathway; induced by caspofungin
References
Irie K, et al. (1993 May). MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Zhang Z, et al. (2005). Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.
de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04814
EOG8JDFR0
sce:PBS2
Genes: 34
EOG8JDFR0
sce:PBS2
Genes: 34
SGD Description
MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
PomBase Description
MAP kinase kinase Wis1
AspGD Description
Ortholog(s) have MAP kinase kinase activity, MAP-kinase scaffold activity, non-membrane spanning protein tyrosine kinase activity
References
Boguslawski G, et al. (1987 Aug). Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.
Boguslawski G, et al. (1992 Nov). PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae.
Brewster JL, et al. (1993 Mar 19). An osmosensing signal transduction pathway in yeast.
Kahn RA, et al. (1995 Jan 6). Mutational analysis of Saccharomyces cerevisiae ARF1.
Maeda T, et al. (1995 Jul 28). Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.
Raitt DC, et al. (2000 Sep 1). Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.
Han KH, et al. (2002 Mar). Osmotic stress-coupled maintenance of polar growth in Aspergillus nidulans.
Mapes J, et al. (2004 Jan 28). Nbp2 targets the Ptc1-type 2C Ser/Thr phosphatase to the HOG MAPK pathway.
Cullen PJ, et al. (2004 Jul 15). A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.
Marles JA, et al. (2004 Jun 18). Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast.
Furukawa K, et al. (2005 Jun). Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress.
Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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FOG04815
EOG8JDFR0
sce:STE7
Genes: 33
EOG8JDFR0
sce:STE7
Genes: 33
SGD Description
Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway
PomBase Description
MAP kinase kinase Byr1
AspGD Description
Ortholog(s) have MAP kinase kinase activity
References
Teague MA, et al. (1986 Oct). Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.
Cairns BR, et al. (1992 Jul). Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.
Zheng CF, et al. (1994 Mar 1). Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
Clark KL, et al. (1995 Dec 20). Constitutive activation of the Saccharomyces cerevisiae mating response pathway by a MAP kinase kinase from Candida albicans.
Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.
Bayram Ö, et al. (2012). The Aspergillus nidulans MAPK module AnSte11-Ste50-Ste7-Fus3 controls development and secondary metabolism.
Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Gibbons JG, et al. (2013 Jan). The function and evolution of the Aspergillus genome.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
7 genes with posterior transmembrane prediction > 50% |
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