FOG04793
EOG8JM65M

sce:GPA1

Genes: 33

SGD Description
Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress


AspGD Description
Heterotrimeric G-protein alpha-subunit; expressed in germinating conidia


References

Sadhu C, et al. (1992 May). A G-protein alpha subunit from asexual Candida albicans functions in the mating signal transduction pathway of Saccharomyces cerevisiae and is regulated by the a1-alpha 2 repressor.

Yu JH, et al. (1996 Oct 1). The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development.

Hicks JK, et al. (1997 Aug 15). Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway.

Wieser J, et al. (1997 Sep). Dominant mutations affecting both sporulation and sterigmatocystin biosynthesis in Aspergillus nidulans.

Adams TH, et al. (1998 Dec). Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans.

Yu JH, et al. (1999 Jan). Extragenic suppressors of loss-of-function mutations in the aspergillus FlbA regulator of G-protein signaling domain protein.

Butchko RA, et al. (1999 Oct). Aspergillus nidulans mutants defective in stc gene cluster regulation.

Rosén S, et al. (1999 Oct 15). The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation.

Coca MA, et al. (2000 Apr). Heterotrimeric G-proteins of a filamentous fungus regulate cell wall composition and susceptibility to a plant PR-5 protein.

Tag A, et al. (2000 Nov). G-protein signalling mediates differential production of toxic secondary metabolites.

Shimizu K, et al. (2001 Feb). Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans.

Saviñón-Tejeda AL, et al. (2001 Jan). The KlGpa1 gene encodes a G-protein alpha subunit that is a positive control element in the mating pathway of the budding yeast Kluyveromyces lactis.

D'Souza CA, et al. (2001 Jul). Characterization of the role of the FluG protein in asexual development of Aspergillus nidulans.

Han KH, et al. (2001 Jul). The nsdD gene encodes a putative GATA-type transcription factor necessary for sexual development of Aspergillus nidulans.

Hicks J, et al. (2001 Mar). RcoA has pleiotropic effects on Aspergillus nidulans cellular development.

Zuber S, et al. (2002 Jun). G-protein signaling mediates asexual development at 25 degrees C but has no effect on yeast-like growth at 37 degrees C in the dimorphic fungus Penicillium mameffei.

Jeong HY, et al. (2003 Mar). Expression of the mnpA gene that encodes the mannoprotein of Aspergillus nidulans is dependent on fadA and flbA as well as veA.

Brakhage AA, et al. (2004). Regulation of penicillin biosynthesis in filamentous fungi.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Bok JW, et al. (2004 Apr). LaeA, a regulator of secondary metabolism in Aspergillus spp.

Emri T, et al. (2004 Jul-Sep). Effect of vitamin E on autolysis and sporulation of Aspergillus nidulans.

Molnár Z, et al. (2004 Jul-Sep). Influence of fadAG203R and deltaflbA mutations on morphology and physiology of submerged Aspergillus nidulans cultures.

Han KH, et al. (2004 Mar). A putative G protein-coupled receptor negatively controls sexual development in Aspergillus nidulans.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Choi CJ, et al. (2005 Jul). Isolation and characterization of the Aspergillus nidulans eglC gene encoding a putative beta-1,3-endoglucanase.

Leiter E, et al. (2005 Jun). Antifungal protein PAF severely affects the integrity of the plasma membrane of Aspergillus nidulans and induces an apoptosis-like phenotype.

Lafon A, et al. (2005 Sep). The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans.

Seo JA, et al. (2005 Sep). Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulans.

Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.

Seo JA, et al. (2006 Feb). The phosducin-like protein PhnA is required for Gbetagamma-mediated signaling for vegetative growth, developmental control, and toxin biosynthesis in Aspergillus nidulans.

Schardl CL, et al. (2006 Jan). A global view of metabolites.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Mah JH, et al. (2006 Oct). Upstream and downstream regulation of asexual development in Aspergillus fumigatus.

Yu JH, et al. (2006 Oct). Growth and developmental control in the model and pathogenic aspergilli.

Paoletti M, et al. (2007 Aug 21). Mating type and the genetic basis of self-fertility in the model fungus Aspergillus nidulans.

Yu HY, et al. (2008 Feb). Functional analyses of heterotrimeric G protein G alpha and G beta subunits in Gibberella zeae.

Calvo AM, et al. (2008 Jul). The VeA regulatory system and its role in morphological and chemical development in fungi.

Emri T, et al. (2008 Jun). Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.

Han KH, et al. (2008 Mar). The Aspergillus nidulans esdC (early sexual development) gene is necessary for sexual development and is controlled by veA and a heterotrimeric G protein.

Soriani FM, et al. (2008 Mar). Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Ogawa M, et al. (2010 Jan). Genetic analysis of conidiation regulatory pathways in koji-mold Aspergillus oryzae.

Szilágyi M, et al. (2010 Mar). MeaB-dependent nutrition sensing regulates autolysis in carbon starved Aspergillus nidulans cultures.

Szilágyi M, et al. (2011 Dec). Extracellular proteinase formation in carbon starving Aspergillus nidulans cultures--physiological function and regulation.

Park HS, et al. (2012 Dec). Genetic control of asexual sporulation in filamentous fungi.

Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.

Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.

Kong Q, et al. (2013). Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus.

Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG04794
EOG8JM65M

sce:GPA2

Genes: 31

SGD Description
Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus


PomBase Description
heterotrimeric G protein alpha-2 subunit Gpa2


AspGD Description
G-protein alpha subunit; possible role in conidium formation, negative regulation of conidium formation, spore germination, trehalose catabolism; expressed in dormant conidia


References

Nakafuku M, et al. (1988 Mar). Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions.

Saviñón-Tejeda AL, et al. (1996 Sep 15). Isolation of a gene encoding a G protein alpha subunit involved in the regulation of cAMP levels in the yeast Kluyveromyces lactis.

Versele M, et al. (1999 Oct 15). A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2.

Harashima T, et al. (2002 Jul). The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Chang MH, et al. (2004 Jul). The GanB Galpha-protein negatively regulates asexual sporulation and plays a positive role in conidial germination in Aspergillus nidulans.

Han KH, et al. (2004 Jul). Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signalling.

Fedorova ND, et al. (2005 Dec 8). Comparative analysis of programmed cell death pathways in filamentous fungi.

Harashima T, et al. (2005 Oct). Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae.

Lafon A, et al. (2005 Sep). The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans.

Molnár Z, et al. (2006). Effects of mutations in the GanB/RgsA G protein mediated signalling on the autolysis of Aspergillus nidulans.

Yu JH, et al. (2006 Apr). Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans.

Lafon A, et al. (2006 Jul). G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective.

Yu JH, et al. (2006 Oct). Growth and developmental control in the model and pathogenic aspergilli.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Yu HY, et al. (2008 Feb). Functional analyses of heterotrimeric G protein G alpha and G beta subunits in Gibberella zeae.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Szilágyi M, et al. (2010 Mar). MeaB-dependent nutrition sensing regulates autolysis in carbon starved Aspergillus nidulans cultures.

Szilágyi M, et al. (2011 Dec). Extracellular proteinase formation in carbon starving Aspergillus nidulans cultures--physiological function and regulation.

Park HS, et al. (2012 Dec). Genetic control of asexual sporulation in filamentous fungi.

Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.

Kwon NJ, et al. (2012 Nov). The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus.

Kong Q, et al. (2013). Gβ-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus.

Krijgsheld P, et al. (2013 Mar 15). Development in Aspergillus.

Cai ZD, et al. (2015 Aug). The Gβ-like protein CpcB is required for hyphal growth, conidiophore morphology and pathogenicity in Aspergillus fumigatus.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%

FOG04795
EOG8JM65M

sce:absent

Genes: 6

PomBase Description
G-protein alpha subunit


AspGD Description
Ortholog(s) have role in MAPK cascade involved in ascospore formation, MAPK cascade involved in conjugation with cellular fusion and mitotic cell cycle arrest in response to pheromone, more

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%