FOG04785
EOG8JSXRZ

sce:SPC2

Genes: 29

SGD Description
Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p


PomBase Description
signal peptidase subunit Spc2 (predicted)


AspGD Description
Putative signal peptidase complex subunit; expression enhanced by maltose


References

Mullins C, et al. (1996 Nov 15). Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct.

Meyer HA, et al. (1997 May 16). The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity.

Antonin W, et al. (2000 Nov 3). Interactions between Spc2p and other components of the endoplasmic reticulum translocation sites of the yeast Saccharomyces cerevisiae.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Henry TC, et al. (2011 Feb). Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Estill M, et al. (2015 May). Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%