FOG04772
EOG8K0P3C

sce:RAD16

Genes: 33

SGD Description
Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex


PomBase Description
Rad16 homolog ATP-dependent DNA helicase/ ubiquitin protein ligase E3 Rhp16


AspGD Description
Ortholog(s) have role in nucleotide-excision repair, pyrimidine dimer repair and nucleotide-excision repair complex localization


References

Bang DD, et al. (1992 Aug 11). Molecular cloning of RAD16, a gene involved in differential repair in Saccharomyces cerevisiae.

Mannhaupt G, et al. (1992 May). Molecular analysis of yeast chromosome II between CMD1 and LYS2: the excision repair gene RAD16 located in this region belongs to a novel group of double-finger proteins.

Schild D, et al. (1992 May). Identification of RAD16, a yeast excision repair gene homologous to the recombinational repair gene RAD54 and to the SNF2 gene involved in transcriptional activation.

Reed SH, et al. (1999 Dec 1). Yeast autonomously replicating sequence binding factor is involved in nucleotide excision repair.

Yu S, et al. (2004 Mar 4). The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04773
EOG8K0P3C

sce:RAD5

Genes: 32

SGD Description
DNA helicase/Ubiquitin ligase; involved in error-free branch of DNA damage tolerance (DDT) pathway; proposed to promote replication fork regression during postreplication repair by template switching; stimulates synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells


PomBase Description
ubiquitin-protein ligase E3 Rad8


AspGD Description
Ortholog(s) have role in nucleotide-excision repair, postreplication repair and nucleus, site of double-strand break localization


References

Ahne F, et al. (1992 Oct). The REV2 gene of Saccharomyces cerevisiae: cloning and DNA sequence.

Johnson RE, et al. (1992 Sep). Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome.

Johnson RE, et al. (1994 Nov 11). Yeast DNA repair protein RAD5 that promotes instability of simple repetitive sequences is a DNA-dependent ATPase.

Ahne F, et al. (1997 Feb 15). The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae.

Xiao W, et al. (2000 Aug). The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways.

Ulrich HD, et al. (2000 Jul 3). Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

Torres-Ramos CA, et al. (2002 Apr). Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae.

Hoege C, et al. (2002 Sep 12). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Ulrich HD, et al. (2003 Feb 28). Protein-protein interactions within an E2-RING finger complex. Implications for ubiquitin-dependent DNA damage repair.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Chen S, et al. (2005). The RING finger ATPase Rad5p of Saccharomyces cerevisiae contributes to DNA double-strand break repair in a ubiquitin-independent manner.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%

FOG04774
EOG8K0P3C

sce:absent

Genes: 5

AspGD Description
Has domain(s) with predicted ATP binding, DNA binding, helicase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides and nucleic acid binding, more

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%