FOG04751
EOG8M0CN0

sce:TIM23

Genes: 33

SGD Description
Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane


PomBase Description
TIM23 translocase complex subunit Tim23 (predicted)


AspGD Description
Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity, role in protein import into mitochondrial matrix and mitochondrial inner membrane presequence translocase complex, plasma membrane localization


References

Emtage JL, et al. (1993 Sep). MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway.

Dekker PJ, et al. (1993 Sep 6). Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane.

Kübrich M, et al. (1994 Aug 1). The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site.

Donzeau M, et al. (2000 May 12). Tim23 links the inner and outer mitochondrial membranes.

Chacinska A, et al. (2005 Mar 25). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Popov-Celeketić D, et al. (2008 May 21). Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 32 genes with posterior transmembrane prediction > 50%

FOG04752
EOG8M0CN0

sce:TIM17

Genes: 33

SGD Description
Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex)


PomBase Description
TIM23 translocase complex subunit Tim17 (predicted)


AspGD Description
Ortholog(s) have protein channel activity, role in mitochondrial genome maintenance, protein import into mitochondrial matrix and mitochondrial inner membrane presequence translocase complex localization


References

Kübrich M, et al. (1994 Aug 1). The polytopic mitochondrial inner membrane proteins MIM17 and MIM23 operate at the same preprotein import site.

Maarse AC, et al. (1994 Aug 1). Identification of the essential yeast protein MIM17, an integral mitochondrial inner membrane protein involved in protein import.

Ryan KR, et al. (1994 May). SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import.

Chacinska A, et al. (2005 Mar 25). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17.

Meier S, et al. (2005 Mar 4). Conserved N-terminal negative charges in the Tim17 subunit of the TIM23 translocase play a critical role in the import of preproteins into mitochondria.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Wrobel L, et al. (2016 Jun 6). The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%

FOG04753
EOG8M0CN0

sce:TIM22

Genes: 32

SGD Description
Essential core component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported


PomBase Description
TIM22 inner membrane protein import complex subunit Tim22 (predicted)


AspGD Description
Ortholog(s) have mitochondrion targeting sequence binding, protein channel activity, role in protein import into mitochondrial inner membrane and mitochondrial inner membrane protein insertion complex, plasma membrane localization


References

Sirrenberg C, et al. (1996 Dec 12). Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22.

Sirrenberg C, et al. (1998 Feb 26). Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5.

Koehler CM, et al. (1998 Jan 16). Import of mitochondrial carriers mediated by essential proteins of the intermembrane space.

Kurz M, et al. (1999 Jul). Biogenesis of Tim proteins of the mitochondrial carrier import pathway: differential targeting mechanisms and crossing over with the main import pathway.

Koehler CM, et al. (2000 Feb). Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane.

Kovermann P, et al. (2002 Feb). Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel.

Rehling P, et al. (2003 Mar 14). Protein insertion into the mitochondrial inner membrane by a twin-pore translocase.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Wrobel L, et al. (2016 Jun 6). The presence of disulfide bonds reveals an evolutionarily conserved mechanism involved in mitochondrial protein translocase assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%