FOG04729
EOG8MSBD9

sce:LCD1

Genes: 22

SGD Description
Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress


PomBase Description
Schizosaccharomyces pombe specific protein Mug100


References

Paciotti V, et al. (2000 Aug 15). The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.

Rouse J, et al. (2000 Nov 1). LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae.

Wakayama T, et al. (2001 Feb). Pie1, a protein interacting with Mec1, controls cell growth and checkpoint responses in Saccharomyces cerevisiae.

Paciotti V, et al. (2001 Jun). Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.

Melo JA, et al. (2001 Nov 1). Two checkpoint complexes are independently recruited to sites of DNA damage in vivo.

Clerici M, et al. (2001 Nov 15). Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.

Rouse J, et al. (2002 Apr). Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo.

Enomoto S, et al. (2002 Aug). MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.

Zou L, et al. (2003 Jun 6). Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Lisby M, et al. (2004 Sep 17). Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins.

Nakada D, et al. (2005 Nov). Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage.

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Ma JL, et al. (2006 Feb 17). Activation of the checkpoint kinase Rad53 by the phosphatidyl inositol kinase-like kinase Mec1.

Ikebe C, et al. (2011). Systematic localization study on novel proteins encoded by meiotically up-regulated ORFs in fission yeast.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 12 genes with posterior transmembrane prediction > 50%