FOG04724
EOG8N02VW

sce:MRC1

Genes: 20

SGD Description
S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; mammalian claspin homolog


References

Kern L, et al. (1990 Sep 11). The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase.

Alcasabas AA, et al. (2001 Nov). Mrc1 transduces signals of DNA replication stress to activate Rad53.

Katou Y, et al. (2003 Aug 28). S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.

Osborn AJ, et al. (2003 Jul 15). Mrc1 is a replication fork component whose phosphorylation in response to DNA replication stress activates Rad53.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%