FOG04693
EOG8NVX69

sce:DAM1

Genes: 22

SGD Description
Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments


PomBase Description
DASH complex subunit Dam1


AspGD Description
Has domain(s) with predicted role in attachment of spindle microtubules to kinetochore, mitotic spindle organization in nucleus and DASH complex, mitotic spindle localization


References

Hofmann C, et al. (1998 Nov 16). Saccharomyces cerevisiae Duo1p and Dam1p, novel proteins involved in mitotic spindle function.

Jones MH, et al. (1999 Jul). Yeast Dam1p is required to maintain spindle integrity during mitosis and interacts with the Mps1p kinase.

Cheeseman IM, et al. (2001 Jan 8). Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex.

Jones MH, et al. (2001 Nov 20). Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle.

Kang J, et al. (2001 Nov 26). Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation.

Cheeseman IM, et al. (2002 Oct 18). Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p.

Shang C, et al. (2003 Aug). Kinetochore protein interactions and their regulation by the Aurora kinase Ipl1p.

Liu X, et al. (2005 Aug 17). Molecular analysis of kinetochore architecture in fission yeast.

Sanchez-Perez I, et al. (2005 Aug 17). The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast.

Miranda JJ, et al. (2005 Feb). The yeast DASH complex forms closed rings on microtubules.

Westermann S, et al. (2005 Jan 21). Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.

Joglekar AP, et al. (2006 Jun). Molecular architecture of a kinetochore-microtubule attachment site.

Asbury CL, et al. (2006 Jun 27). The Dam1 kinetochore complex harnesses microtubule dynamics to produce force and movement.

Westermann S, et al. (2006 Mar 23). The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends.

Franco A, et al. (2007 Oct 1). The Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast.

Gachet Y, et al. (2008 Apr). Sister kinetochore recapture in fission yeast occurs by two distinct mechanisms, both requiring Dam1 and Klp2.

Griffiths K, et al. (2008 Apr 11). Fission yeast dam1-A8 mutant is resistant to and rescued by an anti-microtubule agent.

Kennedy PJ, et al. (2008 Nov). A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe.

Gao Q, et al. (2010 Jul 27). A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast.

Hsu KS, et al. (2011 Feb 8). Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.

Lando D, et al. (2012). The S. pombe histone H2A dioxygenase Ofd2 regulates gene expression during hypoxia.

Buttrick GJ, et al. (2012 Apr 1). Plo1 phosphorylates Dam1 to promote chromosome bi-orientation in fission yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Shepperd LA, et al. (2012 May 22). Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.

Hou H, et al. (2012 Nov 26). Csi1 links centromeres to the nuclear envelope for centromere clustering.

Syrovatkina V, et al. (2013 Dec 2). Antagonistic spindle motors and MAPs regulate metaphase spindle length and chromosome segregation.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Rallis C, et al. (2014 Feb 15). Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%