FOG04688
EOG81C5BH
EOG8P2NHM
sce:MPH1
Genes: 34
EOG81C5BH
EOG8P2NHM
sce:MPH1
Genes: 34
SGD Description
3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA in error-free bypass pathway, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; similar to FANCM human Fanconi anemia complementation group protein that with MHF complex is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases
PomBase Description
ATP-dependent 3' to 5' DNA helicase, FANCM ortholog Fml1
AspGD Description
Ortholog(s) have ATP-dependent four-way junction helicase activity, four-way junction DNA binding activity
References
Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).
Entian KD, et al. (1999 Dec). Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach.
Scheller J, et al. (2000 Jul). MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.
Schürer KA, et al. (2004 Apr). Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from Homologous recombination, but not from postreplicative repair.
Lee W, et al. (2005 Aug). Genome-wide requirements for resistance to functionally distinct DNA-damaging agents.
Prakash R, et al. (2005 Mar 4). Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.
Prakash R, et al. (2009 Jan 1). Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.
Yan Z, et al. (2010 Mar 26). A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
7 genes with posterior transmembrane prediction > 50% |
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FOG04689
EOG81C5BH
sce:MPS1
Genes: 33
EOG81C5BH
sce:MPS1
Genes: 33
SGD Description
Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p
PomBase Description
dual specificity protein kinase Mph1
AspGD Description
Ortholog(s) have mitotic spindle pole body localization
References
Poch O, et al. (1994 Jun 15). RPK1, an essential yeast protein kinase involved in the regulation of the onset of mitosis, shows homology to mammalian dual-specificity kinases.
Lauzé E, et al. (1995 Apr 18). Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase.
Friedman DB, et al. (2001 May 25). Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-terminal domain.
Holinger EP, et al. (2009 May 8). Budding yeast centrosome duplication requires stabilization of Spc29 via Mps1-mediated phosphorylation.
Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.
De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.
Edgerton H, et al. (2015 Feb). Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04690
EOG8P2NHM
sce:absent
Genes: 2
EOG8P2NHM
sce:absent
Genes: 2
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04691
EOG8P2NHM
sce:absent
Genes: 1
EOG8P2NHM
sce:absent
Genes: 1
PomBase Description
ATP-dependent 3' to 5' DNA helicase (predicted)
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
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| Phobius transmembrane predictions
1 genes with posterior transmembrane prediction > 50% |
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