FOG04642
EOG8PVMKR

sce:PAM18

Genes: 33

SGD Description
Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p


PomBase Description
TIM23 translocase complex subunit Tim14 (predicted)


AspGD Description
Ortholog(s) have mitochondrion localization


References

Truscott KN, et al. (2003 Nov 24). A J-protein is an essential subunit of the presequence translocase-associated protein import motor of mitochondria.

D'Silva PD, et al. (2003 Nov 25). J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix.

Mokranjac D, et al. (2003 Oct 1). Tim14, a novel key component of the import motor of the TIM23 protein translocase of mitochondria.

Frazier AE, et al. (2004 Mar). Pam16 has an essential role in the mitochondrial protein import motor.

Li Y, et al. (2004 Sep 3). The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18.

D'Silva PR, et al. (2005 Aug 30). Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane.

van der Laan M, et al. (2005 Sep). Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.

Shaaban MI, et al. (2010 Dec). Suppressor mutagenesis identifies a velvet complex remediator of Aspergillus nidulans secondary metabolism.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%

FOG04643
EOG8PVMKR

sce:PAM16

Genes: 30

SGD Description
Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain


PomBase Description
TIM23 translocase complex subunit Tim16 (predicted)


AspGD Description
Ortholog(s) have protein domain specific binding activity, role in protein import into mitochondrial matrix and presequence translocase-associated import motor localization


References

Frazier AE, et al. (2004 Mar). Pam16 has an essential role in the mitochondrial protein import motor.

Kozany C, et al. (2004 Mar). The J domain-related cochaperone Tim16 is a constituent of the mitochondrial TIM23 preprotein translocase.

Li Y, et al. (2004 Sep 3). The presequence translocase-associated protein import motor of mitochondria. Pam16 functions in an antagonistic manner to Pam18.

D'Silva PR, et al. (2005 Aug 30). Role of Pam16's degenerate J domain in protein import across the mitochondrial inner membrane.

van der Laan M, et al. (2005 Sep). Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor.

Mokranjac D, et al. (2005 Sep 9). The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04644
EOG8PVMKR

sce:MDJ2

Genes: 25

SGD Description
Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain


References

Westermann B, et al. (1997 Oct 3). Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae.

Mokranjac D, et al. (2005 Sep 9). The import motor of the yeast mitochondrial TIM23 preprotein translocase contains two different J proteins, Tim14 and Mdj2.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%