FOG04604
EOG8QRFKF

sce:MCM10

Genes: 32

SGD Description
Essential chromatin-associated protein; involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha


PomBase Description
MCM-associated protein Mcm10


AspGD Description
Ortholog(s) have DNA primase activity, single-stranded DNA binding activity


References

Solomon NA, et al. (1992 Apr). Genetic and molecular analysis of DNA43 and DNA52: two new cell-cycle genes in Saccharomyces cerevisiae.

Merchant AM, et al. (1997 Jun). A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.

Homesley L, et al. (2000 Apr 15). Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.

Kawasaki Y, et al. (2000 Dec). Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae.

Burich R, et al. (2003 Dec). Two bipartite NLSs mediate constitutive nuclear localization of Mcm10.

Cook CR, et al. (2003 Sep 19). A novel zinc finger is required for Mcm10 homocomplex assembly.

Sawyer SL, et al. (2004 Jul 2). Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae.

Ricke RM, et al. (2004 Oct 22). Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

Douglas NL, et al. (2005 Dec). Dual roles for Mcm10 in DNA replication initiation and silencing at the mating-type loci.

Liachko I, et al. (2005 Oct). Mcm10 is required for the maintenance of transcriptional silencing in Saccharomyces cerevisiae.

Das-Bradoo S, et al. (2006 Jul). Interaction between PCNA and diubiquitinated Mcm10 is essential for cell growth in budding yeast.

Ricke RM, et al. (2006 Jul 7). A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%