FOG04595
EOG8QV9VP

sce:CTK2

Genes: 29

SGD Description
Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia


PomBase Description
Lsk1 associated cyclin


AspGD Description
Ortholog(s) have role in positive regulation of septation initiation signaling, regulation of phosphorylation of RNA polymerase II C-terminal domain and cytosol, trimeric positive transcription elongation factor complex b localization


References

Sterner DE, et al. (1995 Oct). The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex.

Lee JM, et al. (1997 Apr 25). Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I.

Hautbergue G, et al. (1999 Apr). The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway.

Hautbergue G, et al. (2001 Mar 16). Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits.

Ostapenko D, et al. (2003 Apr). Budding yeast CTDK-I is required for DNA damage-induced transcription.

Xiao T, et al. (2003 Mar 1). Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast.

Bouchoux C, et al. (2004). CTD kinase I is involved in RNA polymerase I transcription.

Jones JC, et al. (2004 Jun 11). C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats.

Van Driessche B, et al. (2005 Oct 10). Glucose deprivation mediates interaction between CTDK-I and Snf1 in Saccharomyces cerevisiae.

Grenetier S, et al. (2006). CTD kinase I is required for the integrity of the rDNA tandem array.

Karagiannis J, et al. (2007 May 9). A cyclin-dependent kinase that promotes cytokinesis through modulating phosphorylation of the carboxy terminal domain of the RNA Pol II Rpb1p sub-unit.

Coudreuse D, et al. (2010 Jun 22). A gene-specific requirement of RNA polymerase II CTD phosphorylation for sexual differentiation in S. pombe.

Sukegawa Y, et al. (2011 Dec). The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Hu W, et al. (2015 Nov 27). Bulk Segregant Analysis Reveals the Genetic Basis of a Natural Trait Variation in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%

FOG04596
EOG8QV9VP

sce:absent

Genes: 20

PomBase Description
P-TEFB associated cyclin, cyclin T Pch1


AspGD Description
Ortholog(s) have nucleus localization


References

Furnari BA, et al. (1997 May 2). Pch1(+), a second essential C-type cyclin gene in Schizosaccharomyces pombe.

Pei Y, et al. (2003 Feb 28). Interactions between fission yeast Cdk9, its cyclin partner Pch1, and mRNA capping enzyme Pct1 suggest an elongation checkpoint for mRNA quality control.

Pei Y, et al. (2003 Oct 31). Characterization of the Schizosaccharomyces pombe Cdk9/Pch1 protein kinase: Spt5 phosphorylation, autophosphorylation, and mutational analysis.

Pei Y, et al. (2006 Feb). Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Bathe F, et al. (2010 Dec). Functional characterization of a new member of the Cdk9 family in Aspergillus nidulans.

St Amour CV, et al. (2012 Jul). Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition.

Kempf C, et al. (2013 Jan). Evidence that two Pcl-like cyclins control Cdk9 activity during cell differentiation in Aspergillus nidulans asexual development.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 12 genes with posterior transmembrane prediction > 50%

FOG04597
EOG8QV9VP

sce:absent

Genes: 5

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%