FOG04584
EOG8R22D0
sce:HAT2
Genes: 36
EOG8R22D0
sce:HAT2
Genes: 36
SGD Description
Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
PomBase Description
kinetochore protein Mis16
AspGD Description
Ortholog(s) have sequence-specific DNA binding activity and role in CENP-A containing chromatin organization, kinetochore assembly, mitotic sister chromatid segregation, negative regulation of G0 to G1 transition
References
Parthun MR, et al. (1996 Oct 4). The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism.
Ruiz-García AB, et al. (1998 May 15). HAT1 and HAT2 proteins are components of a yeast nuclear histone acetyltransferase enzyme specific for free histone H4.
Machida K, et al. (1999 Feb). Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism.
Kelly TJ, et al. (2000 Oct). Type B histone acetyltransferase Hat1p participates in telomeric silencing.
Taricani L, et al. (2002 Mar 22). The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.
Poveda A, et al. (2004 Apr 16). Hif1 is a component of yeast histone acetyltransferase B, a complex mainly localized in the nucleus.
Ai X, et al. (2004 Apr 23). The nuclear Hat1p/Hat2p complex: a molecular link between type B histone acetyltransferases and chromatin assembly.
Hayashi T, et al. (2004 Sep 17). Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres.
Rosaleny LE, et al. (2005 Aug 1). Yeast HAT1 and HAT2 deletions have different life-span and transcriptome phenotypes.
Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.
Nakazawa N, et al. (2008 Mar 24). Dissection of the essential steps for condensin accumulation at kinetochores and rDNAs during fission yeast mitosis.
Natsume T, et al. (2008 May 21). A DNA polymerase alpha accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast.
Pidoux AL, et al. (2009 Feb 13). Fission yeast Scm3: A CENP-A receptor required for integrity of subkinetochore chromatin.
Williams JS, et al. (2009 Feb 13). Fission yeast Scm3 mediates stable assembly of Cnp1/CENP-A into centromeric chromatin.
Sajiki K, et al. (2009 May 1). Genetic control of cellular quiescence in S. pombe.
Nakamura T, et al. (2012 Sep). Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA.
Tong K, et al. (2012 Sep). Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
Hirai H, et al. (2014). The kinetochore protein Kis1/Eic1/Mis19 ensures the integrity of mitotic spindles through maintenance of kinetochore factors Mis6/CENP-I and CENP-A.
Subramanian L, et al. (2014 Apr 30). Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly.
Hayashi T, et al. (2014 Jul). Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18 to recruit CENP-A through interacting with NMD factors and the SWI/SNF complex.
Li Y, et al. (2014 Jun 1). Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.
An S, et al. (2015 Oct 9). Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp.
Dong Q, et al. (2016 Oct 6). Ccp1 Homodimer Mediates Chromatin Integrity by Antagonizing CENP-A Loading.
Gao C, et al. (2017 Oct). Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in <i>Schizosaccharomyces pombe</i>.
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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FOG04585
EOG8BZKJJ
EOG8R22D0
sce:MSI1
Genes: 26
EOG8BZKJJ
EOG8R22D0
sce:MSI1
Genes: 26
SGD Description
Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase
References
Ruggieri R, et al. (1989 Nov). MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae.
Kaufman PD, et al. (1997 Feb 1). Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I.
Johnston SD, et al. (2001 Mar). CAC3(MSI1) suppression of RAS2(G19V) is independent of chromatin assembly factor I and mediated by NPR1.
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG04586
EOG8R22D0
sce:absent
Genes: 1
EOG8R22D0
sce:absent
Genes: 1
PomBase Description
Clr6 histone deacetylase complex subunit Prw1
References
Nakayama J, et al. (2003 Jun 2). Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.
Nicolas E, et al. (2007 May). Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.
Shevchenko A, et al. (2008). Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.
Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.
Zilio N, et al. (2014 Sep 15). A novel histone deacetylase complex in the control of transcription and genome stability.
Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.
Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
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