FOG04579
EOG8RBP2Q

sce:SPT20

Genes: 34

SGD Description
Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay


PomBase Description
SAGA complex subunit Spt20


AspGD Description
Protein of unknown function


References

Marcus GA, et al. (1996 Jun). ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.

Roberts SM, et al. (1996 Jun). SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiae.

Horiuchi J, et al. (1997 Jun). ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Grant PA, et al. (1998 Dec). The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Grant PA, et al. (1998 Jul 10). A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Marchais V, et al. (2005 Apr 1). DNA array analysis of Candida albicans gene expression in response to adherence to polystyrene.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Liu TT, et al. (2005 Jun). Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

Cuthbertson BJ, et al. (2008 Feb 1). Characterization of zfs1 as an mRNA-binding and -destabilizing protein in Schizosaccharomyces pombe.

Helmlinger D, et al. (2008 Nov 15). The S. pombe SAGA complex controls the switch from proliferation to sexual differentiation through the opposing roles of its subunits Gcn5 and Spt8.

Sellam A, et al. (2009 May). Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans.

Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.

Helmlinger D, et al. (2011 Jun 3). Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.

Tan X, et al. (2014). The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lei B, et al. (2014 Sep 15). Septin ring assembly is regulated by Spt20, a structural subunit of the SAGA complex.

Mojardín L, et al. (2015). Chromosome segregation and organization are targets of 5'-Fluorouracil in eukaryotic cells.

Nie M, et al. (2015 Sep 25). High Confidence Fission Yeast SUMO Conjugates Identified by Tandem Denaturing Affinity Purification.

Malecki M, et al. (2016). Identifying genes required for respiratory growth of fission yeast.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%