FOG04560
EOG8RJDNG

sce:SPC1

Genes: 13

SGD Description
Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress


PomBase Description
Schizosaccharomyces pombe specific protein|signal peptidase complex subunit Spc1 (predicted)


AspGD Description
Has domain(s) with predicted peptidase activity, role in signal peptide processing and integral component of membrane, signal peptidase complex localization


References

Fang H, et al. (1996 Jul 12). The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae.

Meyer HA, et al. (1997 May 16). The yeast SPC22/23 homolog Spc3p is essential for signal peptidase activity.

Antonin W, et al. (2000 Nov 3). Interactions between Spc2p and other components of the endoplasmic reticulum translocation sites of the yeast Saccharomyces cerevisiae.

Decottignies A, et al. (2003 Mar). Schizosaccharomyces pombe essential genes: a pilot study.

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Bitton DA, et al. (2011 Apr). Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.

Sugiyama T, et al. (2011 Mar 16). Red1 promotes the elimination of meiosis-specific mRNAs in vegetatively growing fission yeast.

Sugiyama T, et al. (2012). Rhn1, a nuclear protein, is required for suppression of meiotic mRNAs in mitotically dividing fission yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Sugiyama T, et al. (2013 Jul). Red5 and three nuclear pore components are essential for efficient suppression of specific mRNAs during vegetative growth of fission yeast.

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%