FOG04516
EOG8SBCCS

sce:EDE1

Genes: 35

SGD Description
Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15


PomBase Description
EPS15 repeat family actin cortical patch component (predicted)


AspGD Description
Ortholog(s) have cell cortex localization


References

Gagny B, et al. (2000 Sep). A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis.

Ni L, et al. (2001 Jul). A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae.

Aguilar RC, et al. (2003 Mar 21). The yeast Epsin Ent1 is recruited to membranes through multiple independent interactions.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Kaksonen M, et al. (2005 Oct 21). A modular design for the clathrin- and actin-mediated endocytosis machinery.

Swanson KA, et al. (2006 May 5). Structural basis for monoubiquitin recognition by the Ede1 UBA domain.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Maldonado-Báez L, et al. (2008 Jul). Interaction between Epsin/Yap180 adaptors and the scaffolds Ede1/Pan1 is required for endocytosis.

Stimpson HE, et al. (2009 Nov). Early-arriving Syp1p and Ede1p function in endocytic site placement and formation in budding yeast.

Reider A, et al. (2009 Oct 21). Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation.

Carroll SY, et al. (2012 Feb). Analysis of yeast endocytic site formation and maturation through a regulatory transition point.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 3 genes with posterior transmembrane prediction > 50%

FOG04517
EOG8SBCCS

sce:absent

Genes: 3

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04518
EOG8SBCCS

sce:absent

Genes: 3

PomBase Description
UBA/EH/EF hand domain protein Ucp8


References

Hartmann-Petersen R, et al. (2003 May). UBA domain containing proteins in fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%