FOG04426
EOG8V9S66
sce:CDC53
Genes: 34
EOG8V9S66
sce:CDC53
Genes: 34
SGD Description
Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
PomBase Description
cullin 1
AspGD Description
Ortholog(s) have role in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, negative regulation of mitotic DNA replication initiation and cytosol, nuclear SCF ubiquitin ligase complex localization
References
Kornitzer D, et al. (1994 Dec 15). Regulated degradation of the transcription factor Gcn4.
Mathias N, et al. (1996 Dec). Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteins.
Drury LS, et al. (1997 Oct 1). The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast.
Feldman RM, et al. (1997 Oct 17). A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
Skowyra D, et al. (1997 Oct 17). F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.
Patton EE, et al. (1998 Mar 1). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
Jaquenoud M, et al. (1998 Sep 15). The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex.
Skowyra D, et al. (1999 Apr 23). Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.
Seol JH, et al. (1999 Jun 15). Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.
Seol JH, et al. (2001 Apr). Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly.
Kus BM, et al. (2004 Feb 15). Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.
Koepp DM, et al. (2006 Apr). The F-box protein Dia2 regulates DNA replication.
Siergiejuk E, et al. (2009 Dec 16). Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
Liu Y, et al. (2009 Nov 4). A longevity protein, Lag2, interacts with SCF complex and regulates SCF function.
von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.
| Mitochondrial localization predictions | ||
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| Phobius transmembrane predictions
8 genes with posterior transmembrane prediction > 50% |
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FOG04427
EOG8V9S66
sce:CUL3
Genes: 32
EOG8V9S66
sce:CUL3
Genes: 32
SGD Description
Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
PomBase Description
cullin 3
AspGD Description
Ortholog(s) have role in hyphal growth and Cul3-RING ubiquitin ligase complex, cytosol localization
References
Kominami K, et al. (1998 Nov). Two F-box/WD-repeat proteins Pop1 and Pop2 form hetero- and homo-complexes together with cullin-1 in the fission yeast SCF (Skp1-Cullin-1-F-box) ubiquitin ligase.
Zhou C, et al. (2001). The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.
Zhou C, et al. (2003 Apr). Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.
Michel JJ, et al. (2003 Jun 20). A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.
Geyer R, et al. (2003 Sep). BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases.
Zhou L, et al. (2005 Jul 15). Nep1, a Schizosaccharomyces pombe deneddylating enzyme.
Liu C, et al. (2005 Nov 16). Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
Ribar B, et al. (2007 Apr). ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Dixon SJ, et al. (2008 Oct 28). Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes.
Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.
Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.
Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.
Takeda K, et al. (2011). Identification of genes affecting the toxicity of anti-cancer drug bortezomib by genome-wide screening in S. pombe.
Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.
von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.
Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.
Sun LL, et al. (2013). Global analysis of fission yeast mating genes reveals new autophagy factors.
Fontebasso Y, et al. (2013 Dec). The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Malecki M, et al. (2016 Nov 25). Functional and regulatory profiling of energy metabolism in fission yeast.
Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.
Dudin O, et al. (2017 Apr). A systematic screen for morphological abnormalities during fission yeast sexual reproduction identifies a mechanism of actin aster formation for cell fusion.
| Mitochondrial localization predictions | ||
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| Raw data
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| Phobius transmembrane predictions
2 genes with posterior transmembrane prediction > 50% |
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FOG04428
EOG8V9S66
sce:absent
Genes: 9
EOG8V9S66
sce:absent
Genes: 9
PomBase Description
cullin 4
AspGD Description
Ortholog(s) have role in cellular protein localization, chromatin silencing at centromere, chromatin silencing at silent mating-type cassette and chromatin silencing at telomere, more
References
Osaka F, et al. (2000 Jul 3). Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast.
Ding DQ, et al. (2000 Mar). Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Liu C, et al. (2003 May 1). Cop9/signalosome subunits and Pcu4 regulate ribonucleotide reductase by both checkpoint-dependent and -independent mechanisms.
Holmberg C, et al. (2005 Apr 1). Ddb1 controls genome stability and meiosis in fission yeast.
Thon G, et al. (2005 Dec). The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe.
Horn PJ, et al. (2005 Jul 15). A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation.
Zhou L, et al. (2005 Jul 15). Nep1, a Schizosaccharomyces pombe deneddylating enzyme.
Hong EJ, et al. (2005 Jul-Sep). A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation.
Liu C, et al. (2005 Nov 16). Transactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligase.
Jia S, et al. (2005 Oct). Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin.
Hansen KR, et al. (2006). Evolutionary-conserved telomere-linked helicase genes of fission yeast are repressed by silencing factors, RNAi components and the telomere-binding protein Taz1.
Fukumoto Y, et al. (2008 Nov). Schizosaccharomyces pombe Ddb1 recruits substrate-specific adaptor proteins through a novel protein motif, the DDB-box.
Bayne EH, et al. (2010 Mar 5). Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity.
Shanker S, et al. (2010 Oct 28). Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.
Vejrup-Hansen R, et al. (2011 Mar 7). Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.
Arita Y, et al. (2011 May). Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome.
von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.
White SA, et al. (2014). The RFTS domain of Raf2 is required for Cul4 interaction and heterochromatin integrity in fission yeast.
Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).
Kuscu C, et al. (2014 Feb 4). CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing.
Wang J, et al. (2016 Apr 1). The proper connection between shelterin components is required for telomeric heterochromatin assembly.
Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.
| Mitochondrial localization predictions | ||
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| Predotar | TargetP | MitoProt |
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| Raw data
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| Phobius transmembrane predictions
3 genes with posterior transmembrane prediction > 50% |
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