FOG04389
EOG8W0VWZ

sce:PST1;ECM33

Genes: 37

SGD Description
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication|GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication


PomBase Description
GPI anchored cell surface protein involved in ascospore wall assembly Meu10|cell wall protein Ecm33


AspGD Description
Putative cell wall organization protein


References

Lussier M, et al. (1997 Oct). Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae.

Pardo M, et al. (1999 Apr). Two-dimensional analysis of proteins secreted by Saccharomyces cerevisiae regenerating protoplasts: a novel approach to study the cell wall.

Jung US, et al. (1999 Dec). Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway.

Hamada K, et al. (1999 Jul). Amino acid residues in the omega-minus region participate in cellular localization of yeast glycosylphosphatidylinositol-attached proteins.

Davis CA, et al. (2000 Apr 15). Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast.

Terashima H, et al. (2000 Sep). Up-regulation of genes encoding glycosylphosphatidylinositol (GPI)-attached proteins in response to cell wall damage caused by disruption of FKS1 in Saccharomyces cerevisiae.

Bidlingmaier S, et al. (2002 Apr). Large-scale identification of genes important for apical growth in Saccharomyces cerevisiae by directed allele replacement technology (DART) screening.

Ramón AM, et al. (2003 Aug). Diverged binding specificity of Rim101p, the Candida albicans ortholog of PacC.

Terashima H, et al. (2003 Jan 21). The localization change of Ybr078w/Ecm33, a yeast GPI-associated protein, from the plasma membrane to the cell wall, affecting the cellular function.

De Groot PW, et al. (2003 Jul 15). Genome-wide identification of fungal GPI proteins.

Boorsma A, et al. (2004 Apr 15). Characterization of the transcriptional response to cell wall stress in Saccharomyces cerevisiae.

Pardo M, et al. (2004 Dec). PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity.

García-Sánchez S, et al. (2005 Jun). Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the fungal pathogen, Candida albicans.

Liu TT, et al. (2005 Jun). Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

Nobile CJ, et al. (2005 Jun 21). Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p.

Yin QY, et al. (2005 May 27). Comprehensive proteomic analysis of Saccharomyces cerevisiae cell walls: identification of proteins covalently attached via glycosylphosphatidylinositol remnants or mild alkali-sensitive linkages.

Kunze D, et al. (2005 Oct). Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans.

Enjalbert B, et al. (2006 Feb). Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.

Tafforeau L, et al. (2006 Oct 4). Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

de Groot PW, et al. (2007 Apr). Mass spectrometric identification of covalently bound cell wall proteins from the fission yeast Schizosaccharomyces pombe.

Brown SL, et al. (2007 Jan). Reducing haziness in white wine by overexpression of Saccharomyces cerevisiae genes YOL155c and YDR055w.

Reinders J, et al. (2007 Nov). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.

Yin QY, et al. (2007 Sep). Mass spectrometric quantitation of covalently bound cell wall proteins in Saccharomyces cerevisiae.

Alvarez FJ, et al. (2008 Dec). The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.

Luallen RJ, et al. (2008 Jul). An engineered Saccharomyces cerevisiae strain binds the broadly neutralizing human immunodeficiency virus type 1 antibody 2G12 and elicits mannose-specific gp120-binding antibodies.

Mao Y, et al. (2008 Nov). C-terminal signals regulate targeting of glycosylphosphatidylinositol-anchored proteins to the cell wall or plasma membrane in Candida albicans.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

de Groot PW, et al. (2009 Mar). Comprehensive genomic analysis of cell wall genes in Aspergillus nidulans.

Cao W, et al. (2009 Oct). Using a new GPI-anchored-protein identification system to mine the protein databases of Aspergillus fumigatus, Aspergillus nidulans, and Aspergillus oryzae.

Takada H, et al. (2010 Feb 15). The cell surface protein gene ecm33+ is a target of the two transcription factors Atf1 and Mbx1 and negatively regulates Pmk1 MAPK cell integrity signaling in fission yeast.

Synnott JM, et al. (2010 Nov). Regulation of the hypoxic response in Candida albicans.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Jaiseng W, et al. (2012). Studies on the roles of clathrin-mediated membrane trafficking and zinc transporter Cis4 in the transport of GPI-anchored proteins in fission yeast.

Fang Y, et al. (2014). E3 ubiquitin ligase Pub1 is implicated in endocytosis of a GPI-anchored protein Ecm33 in fission yeast.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Garg A, et al. (2015 Aug 18). A new transcription factor for mitosis: in Schizosaccharomyces pombe, the RFX transcription factor Sak1 works with forkhead factors to regulate mitotic expression.

Nakazawa N, et al. (2015 Jun). RNA pol II transcript abundance controls condensin accumulation at mitotically up-regulated and heat-shock-inducible genes in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 25 genes with posterior transmembrane prediction > 50%

FOG04390
EOG8W0VWZ

sce:SPS22;SPS2

Genes: 24

SGD Description
Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall|Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component


References

Percival-Smith A, et al. (1986 Jul). Characterization and mutational analysis of a cluster of three genes expressed preferentially during sporulation of Saccharomyces cerevisiae.

Percival-Smith A, et al. (1987 Jul). Increased copy number of the 5' end of the SPS2 gene inhibits sporulation of Saccharomyces cerevisiae.

Sia RA, et al. (1995 Oct). Stimulation of later functions of the yeast meiotic protein kinase Ime2p by the IDS2 gene product.

Coluccio A, et al. (2004 Dec). Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 17 genes with posterior transmembrane prediction > 50%

FOG04391
EOG8W0VWZ

sce:absent

Genes: 1

AspGD Description
Has domain(s) with predicted membrane localization

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%