FOG04356
EOG8WDBVR

sce:SLD2

Genes: 13

SGD Description
Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress


References

Chéret G, et al. (1993 Nov). The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast.

Kamimura Y, et al. (1998 Oct). Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication.

Wang H, et al. (1999 Mar 30). DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.

Masumoto H, et al. (2002 Feb 7). S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast.

Ubersax JA, et al. (2003 Oct 23). Targets of the cyclin-dependent kinase Cdk1.

Tak YS, et al. (2006 May 3). A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11.

Bloom J, et al. (2007 Feb). Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%