FOG04343
EOG82BVSN
EOG8WH74N

sce:SUR7

Genes: 30

SGD Description
Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)


AspGD Description
Protein similar to multicopy suppressor Sur7p; expression repressed by tunicamycin and DTT


References

Sivadon P, et al. (1997 Jun 30). Cloning of the multicopy suppressor gene SUR7: evidence for a functional relationship between the yeast actin-binding protein Rvs167 and a putative membranous protein.

Navarre C, et al. (2002 Dec). Subproteomics: identification of plasma membrane proteins from the yeast Saccharomyces cerevisiae.

Young ME, et al. (2002 Feb). The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation.

Malinska K, et al. (2004 Dec 1). Distribution of Can1p into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells.

Walther TC, et al. (2006 Feb 23). Eisosomes mark static sites of endocytosis.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Alvarez FJ, et al. (2008 Dec). The Sur7 protein regulates plasma membrane organization and prevents intracellular cell wall growth in Candida albicans.

Silva EM, et al. (2008 Oct). Identification of genes differentially expressed in a strain of the mold Aspergillus nidulans carrying a loss-of-function mutation in the palA gene.

Cabezón V, et al. (2009 Oct). Analysis of Candida albicans plasma membrane proteome.

Bernardo SM, et al. (2010 Apr 30). Candida albicans SUR7 contributes to secretion, biofilm formation, and macrophage killing.

Vangelatos I, et al. (2010 Oct). Eisosome organization in the filamentous ascomycete Aspergillus nidulans.

Sorgo AG, et al. (2011 Aug). Effects of fluconazole on the secretome, the wall proteome, and wall integrity of the clinical fungus Candida albicans.

Scazzocchio C, et al. (2011 Jan). Eisosomes and membrane compartments in the ascomycetes: A view from Aspergillus nidulans.

Wang HX, et al. (2011 Jan). The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength.

Douglas LM, et al. (2012). Sur7 promotes plasma membrane organization and is needed for resistance to stressful conditions and to the invasive growth and virulence of Candida albicans.

Athanasopoulos A, et al. (2013 Apr). Eisosome distribution and localization in the meiotic progeny of Aspergillus nidulans.

She X, et al. (2013 Sep). Cell surface changes in the Candida albicans mitochondrial mutant goa1Δ are associated with reduced recognition by innate immune cells.

Athanasopoulos A, et al. (2015 Oct 15). Characterization of AnNce102 and its role in eisosome stability and sphingolipid biosynthesis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 30 genes with posterior transmembrane prediction > 50%

FOG04344
EOG880GDV
EOG8WH74N

sce:FMP45;

Genes: 21

SGD Description
Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication|Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication


References

Young ME, et al. (2002 Feb). The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation.

Runner VM, et al. (2003 Jul 30). A genetic screen for yeast genes induced by sustained osmotic stress.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Liu X, et al. (2007 Apr). Genetic and comparative transcriptome analysis of bromodomain factor 1 in the salt stress response of Saccharomyces cerevisiae.

White MA, et al. (2007 Jan 19). Characteristics affecting expression and solubilization of yeast membrane proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 21 genes with posterior transmembrane prediction > 50%

FOG04345
EOG8WH74N

sce:absent

Genes: 1

 





 

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%