FOG04316
EOG8NVX1T
EOG8X960T

sce:BIT61;BIT2

Genes: 18

SGD Description
Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication|Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication


PomBase Description
HbrB family protein involved in TOR signaling Bit2 (predicted)|TORC2 subunit Bit61


AspGD Description
Ortholog(s) have role in establishment or maintenance of cell polarity, hyphal growth


References

Ito T, et al. (2001 Apr 10). A comprehensive two-hybrid analysis to explore the yeast protein interactome.

Gatherar IM, et al. (2004 Apr). Identification of a novel gene hbrB required for polarised growth in Aspergillus nidulans.

Reinke A, et al. (2004 Apr 9). TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae.

Fadri M, et al. (2005 Apr). The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%