FOG04283
EOG8Z6162

sce:SRB5

Genes: 25

SGD Description
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance


AspGD Description
Has domain(s) with predicted RNA polymerase II transcription cofactor activity, role in regulation of transcription from RNA polymerase II promoter and mediator complex localization


References

Thompson CM, et al. (1993 Jul 2). A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

Kim YJ, et al. (1994 May 20). A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II.

Koh SS, et al. (1998 May). An activator target in the RNA polymerase II holoenzyme.

Holstege FC, et al. (1998 Nov 25). Dissecting the regulatory circuitry of a eukaryotic genome.

Kang JS, et al. (2001 Nov 9). The structural and functional organization of the yeast mediator complex.

Davis JA, et al. (2002 Aug). Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

van de Peppel J, et al. (2005 Aug 19). Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Takagi Y, et al. (2005 Sep 2). Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Takagi Y, et al. (2006 Aug 4). Head module control of mediator interactions.

Takagi Y, et al. (2006 Jan 6). Mediator as a general transcription factor.

Larivière L, et al. (2006 Oct). Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20.

Baidoobonso SM, et al. (2007 Feb 23). Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%