FOG04270
EOG8ZCRMS

sce:ESC2

Genes: 13

SGD Description
Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member


References

Dhillon N, et al. (2000 Oct). A histone variant, Htz1p, and a Sir1p-like protein, Esc2p, mediate silencing at HMR.

Cuperus G, et al. (2002 Oct). Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.

Novatchkova M, et al. (2005 Feb 7). Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family.

Mimura S, et al. (2010 Mar 26). Cul8/Rtt101 forms a variety of protein complexes that regulate DNA damage response and transcriptional silencing.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%