FOG04260
EOG8ZS7MD
sce:SET1
Genes: 33
EOG8ZS7MD
sce:SET1
Genes: 33
SGD Description
Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain
PomBase Description
histone lysine methyltransferase Set1
AspGD Description
Ortholog(s) have histone methyltransferase activity (H3-K4 specific) activity
References
Nislow C, et al. (1997 Dec). SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.
Corda Y, et al. (1999 Feb). Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions.
Briggs SD, et al. (2001 Dec 15). Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.
Roguev A, et al. (2001 Dec 17). The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.
Miller T, et al. (2001 Nov 6). COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.
Bryk M, et al. (2002 Jan 22). Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.
Nagy PL, et al. (2002 Jan 8). A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.
Bernstein BE, et al. (2002 Jun 25). Methylation of histone H3 Lys 4 in coding regions of active genes.
Krogan NJ, et al. (2002 Mar 29). COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.
Santos-Rosa H, et al. (2002 Sep 26). Active genes are tri-methylated at K4 of histone H3.
Boa S, et al. (2003 Jul 15). Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.
Santos-Rosa H, et al. (2003 Nov). Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
Morillon A, et al. (2005 Jun 10). Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription.
Raman SB, et al. (2006 May). Candida albicans SET1 encodes a histone 3 lysine 4 methyltransferase that contributes to the pathogenesis of invasive candidiasis.
Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG04261
EOG8ZS7MD
sce:SET2
Genes: 32
EOG8ZS7MD
sce:SET2
Genes: 32
SGD Description
Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia
PomBase Description
histone lysine methyltransferase Set2
AspGD Description
Ortholog(s) have histone methyltransferase activity (H3-K36 specific) activity
References
Macias MJ, et al. (2000 May). Structural analysis of WW domains and design of a WW prototype.
Li J, et al. (2002 Dec 20). Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.
Strahl BD, et al. (2002 Mar). Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression.
Krogan NJ, et al. (2003 Jun). Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.
Xiao T, et al. (2003 Mar 1). Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast.
Li B, et al. (2003 Mar 14). The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Schaft D, et al. (2003 May 15). The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation.
Landry J, et al. (2003 Sep). Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.
Kizer KO, et al. (2005 Apr). A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
Rao B, et al. (2005 Nov). Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide.
Tripic T, et al. (2006 Jan 20). The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation.
Vojnic E, et al. (2006 Jan 6). Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription.
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
FOG04262
EOG8ZS7MD
sce:absent
Genes: 15
EOG8ZS7MD
sce:absent
Genes: 15
AspGD Description
Has domain(s) with predicted histone-lysine N-methyltransferase activity and nucleus localization
| Mitochondrial localization predictions | ||
|---|---|---|
| Predotar | TargetP | MitoProt |
 |
 |
 |
| Raw data
|
||
| Phobius transmembrane predictions
0 genes with posterior transmembrane prediction > 50% |
||
