FOG04253
EOG8ZS7Q0

sce:CCS1

Genes: 32

SGD Description
Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress


PomBase Description
superoxide dismutase copper chaperone Ccs1


AspGD Description
Ortholog(s) have superoxide dismutase copper chaperone activity, role in cellular copper ion homeostasis, cellular response to metal ion, intracellular copper ion transport and cytosol, mitochondrial inner membrane, nucleus localization


References

Horecka J, et al. (1995 Aug 30). Cloning and characterization of the Saccharomyces cerevisiae LYS7 gene: evidence for function outside of lysine biosynthesis.

Culotta VC, et al. (1997 Sep 19). The copper chaperone for superoxide dismutase.

Lamb AL, et al. (1999 Aug). Crystal structure of the copper chaperone for superoxide dismutase.

Hall LT, et al. (2000 Apr 4). X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery.

Lamb AL, et al. (2000 Dec 5). Heterodimer formation between superoxide dismutase and its copper chaperone.

Sturtz LA, et al. (2001 Oct 12). A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage.

Lamb AL, et al. (2001 Sep). Heterodimeric structure of superoxide dismutase in complex with its metallochaperone.

Laliberté J, et al. (2004 Jul 2). The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways.

Peter C, et al. (2008 Oct). Copper distributed by Atx1 is available to copper amine oxidase 1 in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Doi A, et al. (2015 Apr). Chemical genomics approach to identify genes associated with sensitivity to rapamycin in the fission yeast Schizosaccharomyces pombe.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Guo L, et al. (2016 Oct 13). Global Fitness Profiling Identifies Arsenic and Cadmium Tolerance Mechanisms in Fission Yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04254
EOG8ZS7Q0

sce:ATX1

Genes: 27

SGD Description
Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake


AspGD Description
Ortholog(s) have copper chaperone activity and role in cellular copper ion homeostasis, cellular iron ion homeostasis, cellular response to oxidative stress, copper ion transport, regulation of iron ion transmembrane transport


References

Lin SJ, et al. (1995 Apr 25). The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity.

Fujii I, et al. (1996 Nov 27). Cloning of the polyketide synthase gene atX from Aspergillus terreus and its identification as the 6-methylsalicylic acid synthase gene by heterologous expression.

Rosenzweig AC, et al. (1999 Jun 15). Crystal structure of the Atx1 metallochaperone protein at 1.02 A resolution.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%

FOG04255
EOG8ZS7Q0

sce:absent

Genes: 2

PomBase Description
copper chaperone Atx1

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%