FOG04236
EOG812JQ5

sce:NSE1

Genes: 22

SGD Description
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair


PomBase Description
Smc5-6 complex ubiquitin-protein ligase E3 subunit 1


AspGD Description
Ortholog(s) have SUMO transferase activity, role in double-strand break repair via homologous recombination, meiosis I, postreplication repair and Smc5-Smc6 complex, cytosol, nucleus localization


References

Fujioka Y, et al. (2002 Jun 14). Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair.

McDonald WH, et al. (2003 Nov 14). Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.

Harvey SH, et al. (2004 Jan). Coordination of DNA damage responses via the Smc5/Smc6 complex.

Pebernard S, et al. (2004 Nov). Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.

Sergeant J, et al. (2005 Jan). Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex.

Zhao X, et al. (2005 Mar 29). A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

Pebernard S, et al. (2006 Mar). The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Hudson JJ, et al. (2011 Feb 25). Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families.

Tapia-Alveal C, et al. (2014 Jun). H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.

Zilio N, et al. (2014 Sep 15). A novel histone deacetylase complex in the control of transcription and genome stability.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%